{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:42:37Z","timestamp":1792208557659,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN2018\/316"],"award-info":[{"award-number":["CAN2018\/316"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022\u201000651"],"award-info":[{"award-number":["2022\u201000651"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","award":["FoUI\u2010974833"],"award-info":[{"award-number":["FoUI\u2010974833"]}],"id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Men with prostate cancer have a high risk for bleeding when treated with antithrombotics. The aim of this study was to investigate clinical markers for vulnerability for bleeding in these men the last year of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study on deceased patients with advanced prostate cancer admitted to specialized palliative care and treated with antithrombotics the last year of life. Relative risk (RR) was calculated with log\u2010binomial models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 100 men with end\u2010stage prostate cancer, 64 men were treated with antithrombotics. Twenty\u2010four of these (37.5%) suffered from bleeding during the last year of life. Clinical markers associated with an increased vulnerability for bleeding were need of blood transfusion, RR 3.15 (95% CI: 1.34\u20137.39); low thrombocyte count, RR 2.41 (95% CI: 1.39\u20134.16); and deep venous thrombosis treatment, RR 2.44 (95% CI: 1.21\u20134.94). Age, type of antithrombotic, use of steroids, or NSAID were not risk factors. In 50%, antithrombotic treatment continued during the last week in life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Antithrombotic treatment the last year of life is associated with a high risk of bleeding in men with prostate cancer. Clinical markers associated with increased vulnerability for bleeding are low thrombocyte count and need of transfusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70720","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:13:28Z","timestamp":1791879208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Markers of Vulnerability for Bleeding in Men With\u00a0Prostate Cancer and Antithrombotic Treatment"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-9283","authenticated-orcid":false,"given":"Linda","family":"Bj\u00f6rkhem\u2010Bergman","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics Karolinska Institutet  Huddinge Sweden"},{"name":"Stockholms Sjukhems R&amp;D Department  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-7598","authenticated-orcid":false,"given":"Christel","family":"Hedman","sequence":"additional","affiliation":[{"name":"Stockholms Sjukhems R&amp;D Department  Stockholm Sweden"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-0559","authenticated-orcid":false,"given":"M\u00e1t\u00e9","family":"Szilcz","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-0577","authenticated-orcid":false,"given":"Gabriella","family":"Frisk","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society (NVS), Division of Clinical Geriatrics Karolinska Institutet  Huddinge Sweden"},{"name":"ASIH Stockholm S\u00f6dra, Advanced Home Care and Specialized Palliative Ward  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2016.0487"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.02.028"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909118794926"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-020-00315-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12220"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"},{"key":"e_1_2_10_8_1","unstructured":"WHO \u201cATC\/DDD Index 2024 \u201d(2024) https:\/\/www.whocc.no\/atc_ddd_index\/."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00160-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2024.0108"},{"key":"e_1_2_10_11_1","unstructured":"\u201cASIH Stockholm S\u00f6dra (Region Stockholm) \u201d(2023) https:\/\/www.asih.regionstockholm.se\/om\u2010oss\/har\u2010finns\u2010vi1\/sodra\u2010stockholm\/."},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12904-019-0472-z","article-title":"A Comparative Study on Decision and Documentation of Refraining From Resuscitation in Two Medical Home Care Units in Sweden","volume":"18","author":"Sterpu B.","year":"2019","journal-title":"BMC Palliative Care"},{"issue":"19","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029423","article-title":"Common Cancer Types and Risk of Stroke and Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Population\u2010Based Study in England","volume":"12","author":"Ajabnoor A. 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