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This study aimed to investigate its effects on cortical angiogenesis and vasodilation during stroke recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mice underwent distal middle cerebral artery occlusion (dMCAO) and subsequently received NBP treatment. Therapeutic efficacy was measured by neurological deficits and infarct size. Angiogenesis was assessed by immunofluorescent staining. Laser speckle and two\u2010photon microscopy imaging were employed to evaluate dynamic changes in cortical cerebral blood flow and vascular structure in\u00a0vivo. The modulation of the Akt\/GSK\u20103\u03b2 signaling pathway was detected by western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NBP administration promoted neurological recovery and reduced infarct size in the subacute phase. It facilitated cerebral blood flow and vasodilation, enhanced angiogenesis as evidenced by increased BrdU\n                      <jats:sup>+<\/jats:sup>\n                      \/CD31\n                      <jats:sup>+<\/jats:sup>\n                      cells and improved astrocyte\/pericyte coverage around microvessels. Moreover, the pro\u2010angiogenesis effect of NBP depends on the activation of the Akt\/GSK\u20103\u03b2 pathway, and this effect is blocked by LY294002.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, NBP enhances recovery after ischemic stroke by promoting cortical angiogenesis and vasodilation through activation of the Akt\/GSK\u20103\u03b2 pathway. These findings highlight its therapeutic potential for delayed intervention in ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70698","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:07:28Z","timestamp":1765429648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dl\u20103\u2010n\u2010Butylphthalide Promotes Cortical Angiogenesis via Akt\/GSK\u20103\u03b2 Signaling in Ischemic Stroke Mice"],"prefix":"10.1002","volume":"31","author":[{"given":"Lan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Second Hospital of Hebei Medical University  Shijiazhuang Hebei People's Republic of China"},{"name":"Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio\u2010Cerebrovascular Disease  Shijiazhuang Hebei People's Republic of China"},{"name":"The Key Laboratory of 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