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These channels serve as critical sensors for detecting temperature, mechanical forces, and chemical stimuli, thereby regulating numerous physiological and pathological processes. Over the past decade, their pivotal role in neuroimmune crosstalk and inflammatory signaling has emerged as a key focus within neuroscience research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature review was conducted in PubMed using key terms \u201cTRP channel,\u201d \u201cneuroinflammation,\u201d and each of the following neurological disorders: neuropathic pain, migraine, stroke, multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), autism spectrum disorder (ASD), epilepsy, and psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review synthesizes the current evidence to elucidate the dual\u2010edged contributions of TRP channels as mediators of inflammation in neuropathic pain, migraine, stroke, MS, AD, PD, ASD, epilepsy, and psychiatric disorders. Furthermore, we also evaluate emerging therapeutic strategies targeting TRP channels, encompassing both nonpharmacological approaches and pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>By integrating mechanistic insights with translational perspectives, this review highlights TRP channels as promising targets for precision medicine and underscores their potential in the development of novel, mechanism\u2010based therapies for complex neurological disorders, thereby advancing a new era of targeted neuroimmunomodulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70700","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T07:33:18Z","timestamp":1765870398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transient 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Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Xian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Brain, Cognition and Education Science, Ministry of Education South China Normal University  Guangzhou China"},{"name":"Institute for Brain Research and Rehabilitation South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou 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