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It has been associated with dysregulation of the monoaminergic systems. Furthermore, functional abnormalities within the mesolimbic\u2010basal ganglia reward circuit may be involved in the pathogenesis of Parkinson's disease\u2010related depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate monoaminergic deficits and the corresponding changes within the striatum\u2010mesolimbic circuitry in patients with Parkinson's disease and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included eight depressed and 18 non\u2010depressed patients with Parkinson's disease and 28 matched healthy controls. We simultaneously obtained\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluoropropyl\u2010dihydrotetrabenazine positron emission tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FP\u2010DTBZ PET) and resting\u2010state functional magnetic resonance images (rs\u2010fMRI). We also recruited additional patients with Parkinson's disease (nine depressed and 20 non\u2010depressed) for the validation of the rs\u2010fMRI analysis. The\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FP\u2010DTBZ standardized uptake value ratio relative to the occipital lobe was used to quantify monoaminergic deficits in the striatum\u2010mesolimbic subregion. Voxel\u2010 and volume\u2010of\u2010interest\u2010based analyses were performed to investigate the functional connectivity changes in the striatum\u2010mesolimbic circuitry of depressed patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who were depressed exhibited greater monoaminergic deficits in the anterior dorsal and ventral putamen and the nucleus\u2010accumbens than non\u2010depressed patients did. Depression severity was negatively correlated with standardized uptake value ratio in the anterior ventral putamen and the nucleus\u2010accumbens of patients with Parkinson's disease. Compared with non\u2010depressed patients, higher functional connectivity was noted within the striatum\u2010mesolimbic circuit in depressed patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In depressed Parkinson's disease patients, monoaminergic deficits are present alongside abnormally increased connectivity within the striatum\u2010mesolimbic circuitry, highlighting this pathway as a potential target for treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70705","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:44:03Z","timestamp":1766735043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Monoamine Loss and Functional Connectivity Alterations in Patients With Parkinson's Disease and 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