{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:26:30Z","timestamp":1767086790655,"version":"3.48.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0040786"],"award-info":[{"award-number":["P0040786"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0042417"],"award-info":[{"award-number":["P0042417"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0043155"],"award-info":[{"award-number":["P0043155"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0055985"],"award-info":[{"award-number":["P0055985"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate the behavioral aftereffects of a novel noninvasive brain stimulation technique\u2014transcranial pulse stimulation (TPS)\u2014applied over the right motor cortex (rM1) in healthy adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four healthy adults underwent a randomized, subject\u2010 and analyst\u2010 blind, crossover trial, receiving active TPS over the rM1 or control TPS over the vertex in two sessions 24\u2009h apart. Motor performance was assessed using the Nine\u2010Hole Peg Test (NHPT) and the Simple Reaction Time Task (SRTT) before, immediately after, and every 10\u2009min for 40\u2009min after each session. A linear mixed model and post hoc analyses were applied to evaluate the effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant interaction effect (stimulation condition \u00d7 time) was found. The left\u2010hand NHPT performance significantly improved from 10\u2009min post\u2010TPS onward in both conditions (\n                      <jats:italic>p<\/jats:italic>\n                      s \u2264\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single session of rM1\u2010TPS does not yield significant improvements in motor dexterity compared to vertex\u2010TPS. Future well\u2010powered studies with a sham control condition and multiple stimulation sessions are needed to investigate the aftereffects using a combination of neurophysiological and neuroimaging approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study was registered in ClinicalTrial.gov in April 2024 (NCT06312930)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70711","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:35:36Z","timestamp":1766219736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Transcranial Pulse Stimulation of the Primary Motor Cortex on Motor Performance in Healthy Adults: A Randomized Crossover Pilot Study"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9517-1579","authenticated-orcid":false,"given":"Penny Ping","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Kin\u2010Yeung","family":"Chak","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Lai\u2010Di","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Xia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"},{"name":"Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bella Bing\u2010Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam Wei\u2010Li","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim Tian\u2010Ze","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharie Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teris","family":"Cheung","sequence":"additional","affiliation":[{"name":"School of Nursing The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-1804","authenticated-orcid":false,"given":"Georg S.","family":"Kranz","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University  Hong Kong China"},{"name":"Mental Health Research Center (MHRC) The Hong Kong Polytechnic University  Hong 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