{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:23Z","timestamp":1792512863352,"version":"4.5.0"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["1053320230244"],"award-info":[{"award-number":["1053320230244"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20303"],"award-info":[{"award-number":["U22A20303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Substance use disorder (SUD) is a complex, chronic, and relapsing encephalopathy associated with inflammatory processes. This study aims to conduct a bibliometric analysis to elucidate the current landscape, research hotspots, and evolving trends in the field of SUD\u2010related inflammation imbalance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Original research and review articles pertaining to \u201cSUD\u2010inflammation\u201d subject were systematically retrieved from the Web of Science Core Collection (WoSCC) database, encompassing publications from its inception to January 1, 2025. Co\u2010authorship, collaboration, co\u2010citation, and co\u2010occurrence analyses were performed using VOSviewer, and CiteSpace was utilized to identify strongest citation bursts and keyword trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2318 publications on \u201cSUD\u2010inflammation\u201d realm were included. A marked increase in publication output was observed starting in 2019. The United States (US) and China emerged as the most prolific countries. The journal, institution, and author, with the largest number of total publications (NP), were respectively JOURNAL OF ETHNOPHARMACOLOGY, UNIVERSITY OF CALIFORNIA SYSTEM, and Michael Maes. Core terms \u201cmicroglial activation,\u201d \u201coxidative stress,\u201d and \u201cTLR4 signaling\u201d were among the most frequently studied topics. Additionally, the roles of the \u201cgut\u2010immune\u2010brain\u201d axis and N\u2010acetylcysteine in drug addiction have been receiving significant attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This bibliometric study delineates the foundational knowledge structural and mapping of the \u201cSUD\u2010inflammation\u201d field over the past 25\u2009years. The findings provide a comprehensive and data\u2010driven perspective on the evolving research landscape, offering valuable insights for future investigations and resource allocation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70719","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:40:57Z","timestamp":1766220057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Worldwide Research Trends on Substance Use Disorder\u2010Related Inflammatory Imbalances: A Bibliometric Analysis"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5284-4999","authenticated-orcid":false,"given":"Shirui","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-6782","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Clinical Research Center for Medical Imaging in Hunan Province  Changsha China"},{"name":"Department of Radiology Quality Control Center in Hunan Province  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20231023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010024\u201001915\u20108"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1462612"},{"key":"e_1_2_11_5_1","unstructured":"UNODC \u201cUNODC World Drug Report 2024: Harms of World Drug Problem Continue to Mount Amid Expansions in Drug Use and Markets \u201d(2024)."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm5217"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010017\u20100525\u2010z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002443\u20106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010025\u201003013\u20100"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2024.114639"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.172981"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adx0043"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9999146"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010022\u201001223\u20106"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00225"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108368"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156737"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.177"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2014.08.021"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.731933"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102129"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002095"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001986"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40037\u2010021\u201000695\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010077192"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.01.001"},{"key":"e_1_2_11_27_1","unstructured":"Statista Research Department \u201cPer Capita Health Spending by Country 2023 \u201d(2023)."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c05553"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X221099499"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2022_586"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.08.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2516\u201012.2013"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2025.578600"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090830"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2022.2043224"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010023\u201001613\u2010x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.09.006"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.030"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101952"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhae281"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010021\u201002322\u2010z"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108598"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.13655"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.050"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108100"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.9"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0312\u201019.2020"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054040"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35455"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010022\u201006154\u20100"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14143"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.147835"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234809"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac135"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12900"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.173033"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15456"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.650283"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110722"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102285"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102283"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/08989621.2015.1127763"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:20:38Z","timestamp":1767086438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cns.70719"],"URL":"https:\/\/doi.org\/10.1002\/cns.70719","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70719"}}