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This study aimed to investigate whether the mast cell membrane stabilizer Disodium cromoglycate (DSCG) could ameliorate depressive\u2010like behaviors by attenuating mast cell\u2010mediated neuroinflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lipopolysaccharide (LPS)\u2010induced and chronic restraint stress (CRS)\u2010induced mouse models were induced in C57BL\/6 mice to evaluate the therapeutic effect of the DSCG. Depressive\u2010like behaviors were assessed using the sucrose preference test (SPT), tail suspension test (TST), and forced swimming test (FST). Histopathological and molecular changes were examined through immunofluorescence, western blot, RT\u2010qPCR, and ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Firstly, our results indicated that the number of MCs was increased in the brain from LPS\u2010induced depression model mice. Secondly, both CRS and LPS\u2010induced depressive\u2010like behaviors were significantly ameliorated by DSCG. Moreover, treatment with DSCG could down\u2010regulate the expression of MCs\u2010associated genes in the brain of depression model mice. Mechanically, our results displayed that the use of DSCG significantly suppressed the activation of glial cells and the expression of pro\u2010inflammatory factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates that MCs infiltration and activation contribute to neuroinflammation in LPS\u2010induced depressive mice. DSCG exerts its antidepressant effects primarily by modulating MCs\u2010mediated neuroinflammation. These results highlight DSCG as a promising therapeutic candidate for the treatment of inflammation\u2010associated depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70721","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:24:52Z","timestamp":1768911892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disodium Cromoglycate Attenuates the Depressive\u2010Like Behaviors in Mice by Inhibiting Neuroinflammation"],"prefix":"10.1002","volume":"32","author":[{"given":"Yun","family":"Xiao","sequence":"first","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-0497","authenticated-orcid":false,"given":"Yajin","family":"Liao","sequence":"additional","affiliation":[{"name":"The Brain Science Center Beijing Institute of Basic Medical Sciences  Beijing China"},{"name":"Department of Neurology, the Second Affiliated Hospital, Hengyang Medical School University of South China  Hengyang China"},{"name":"NHC Key Laboratory of Neurodegenerative Diseases (University of South China)  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.08.002"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"168","article-title":"Lifetime Prevalence and Age\u2010Of\u2010Onset Distributions of Mental Disorders in the World Health Organization's World Mental Health Survey Initiative","volume":"6","author":"Kessler R. 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