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The delayed memory scores were predicted by using connectome\u2010based predictive modeling in patients with BD at baseline. After 12\u2009weeks of treatment, the patients with BD, whose cognitive function improved (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924), showed activity in the right superior temporal gyrus (STG) and left anterior cingulate cortex (ACC) at baseline. The improvement in cognitive function of patients with BD is distinguished by abnormal activities using support vector machine analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The abnormal frontal\u2010limbic network plays a critical role in the underlying neuropathological mechanism of cognitive impairment in patients with BD. The right STG and left ACC hold the potential to serve as neurobiomarkers for predicting the clinical efficacy of cognitive function treatment. These regions provide additional target options for future physical treatments of cognitive impairment in patients with BD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70730","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T13:25:48Z","timestamp":1767619548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in the Efficacy of Cognitive Function Treatment Related to Functional Patterns in the Frontal\u2010Limbic Network in Patients With Bipolar Disorder"],"prefix":"10.1002","volume":"32","author":[{"given":"Sujuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders The Second Xiangya Hospital of Central South University  Changsha Hunan 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