{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:09:53Z","timestamp":1771153793205,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wang et\u00a0al. identify CXCL10\n                    <jats:sup>high<\/jats:sup>\n                    TNF\u03b1\n                    <jats:sup>high<\/jats:sup>\n                    Ki67\n                    <jats:sup>+<\/jats:sup>\n                    microglia as drivers of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell recruitment during experimental cerebral malaria (ECM). We propose a conservative reframing: rather than asserting a fully validated new taxonomy, CXCL10\n                    <jats:sup>high<\/jats:sup>\n                    microglia should be considered a candidate \u201cneuroimmune endotype\u201d whose translational relevance requires clearly prespecified and testable validation in human disease. Priority validation steps include single\u2010nucleus and spatial transcriptomics of human postmortem tissue, paired plasma\/CSF biomarker correlation, and mechanistic assays of microglial antigen presentation. We caution against strong therapeutic inferences from ECM alone; translational work should first establish reproducible human microglial signatures and clinical correlations before precision\u2010targeted interventions are proposed.\n                  <\/jats:p>","DOI":"10.1002\/cns.70742","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T10:40:38Z","timestamp":1768041638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CXCL<\/scp>\n                    10\n                    <sup>high<\/sup>\n                    Microglia in Cerebral Malaria: Toward Translational Validation"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-2129","authenticated-orcid":false,"given":"Nathkapach K.","family":"Rattanapitoon","sequence":"first","affiliation":[{"name":"FMC Medical Center  Nakhon Ratchasima Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chadaporn N.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Faculty of Allied Health Sciences Burapha University  Chonburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natthawut","family":"Charoenphon","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science Naresuan University  Pitsanulok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-5642","authenticated-orcid":false,"given":"Schawanya K.","family":"Rattanapitoon","sequence":"additional","affiliation":[{"name":"FMC Medical Center  Nakhon Ratchasima Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"e_1_2_1_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70425"},{"key":"e_1_2_1_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052223\u20107"},{"key":"e_1_2_1_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010020\u201003545\u20106"},{"key":"e_1_2_1_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038703\u20102"},{"key":"e_1_2_1_12_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.1217"},{"key":"e_1_2_1_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010025\u201002453\u20105"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T10:59:28Z","timestamp":1771153168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cns.70742"],"URL":"https:\/\/doi.org\/10.1002\/cns.70742","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70742"}}