{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:09:57Z","timestamp":1771153797827,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Nos.82303886,82102823"],"award-info":[{"award-number":["Nos.82303886,82102823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2411404"],"award-info":[{"award-number":["2023YFC2411404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2417505"],"award-info":[{"award-number":["2024YFC2417505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitor (ICI)\u2010associated paraneoplastic syndromes (PS) represent a rare but potentially life\u2010threatening adverse event. Despite the widespread use of ICIs in cancer treatment, the clinical characteristics and risk profiles of PS across different treatment regimens remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed FAERS data (Jan 2011\u2013Jun 2024) to identify PS cases potentially related to ICI use. Reporting odds ratios (RORs) were calculated to evaluate safety signals. Clinical features, time\u2010to\u2010onset, and outcomes were analyzed across different ICI regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 162,493 ICI\u2010associated adverse event reports, 179 PS cases were identified. Disproportionate reporting of PS was observed with PD\u20101 inhibitors (ROR 21.77, 95% CI 16.36\u201328.97), PD\u2010L1 inhibitors (ROR 23.33, 95% CI 14.13\u201338.41), nivolumab plus ipilimumab (ROR 24.21, 95% CI 18.07\u201332.42), and durvalumab plus tremelimumab (ROR 24.55, 95% CI 18.73\u201332.79). PS onset showed a bimodal distribution, with a median time to onset of 6\u2009days, where 42.31% occurring within 30\u2009days and 23.08% after 360\u2009days of treatment initiation. Combination therapy, particularly durvalumab plus tremelimumab, was associated with higher rates of severe outcomes (27.8%). In patients with PS related to ICI therapy, those with lung malignancies are the most commonly represented group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis reveals distinct temporal patterns and safety signals of ICI\u2010associated PS, with higher reporting rates and severity in combination therapy. These findings provide important insights for clinical monitoring strategies and highlight the need for increased vigilance during specific risk windows, particularly in patients receiving combination therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70747","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:10:16Z","timestamp":1768990216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacovigilance Insights Into Immune Checkpoint Inhibitor\u2010Induced Risk of Paraneoplastic Syndrome: A Large\u2010Scale Real World Study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-4433","authenticated-orcid":false,"given":"Bufu","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Zhongshan Hospital, Shanghai Institute of Medical Imaging, National Clinical Research Center 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