{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:38:06Z","timestamp":1792881486560,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271328"],"award-info":[{"award-number":["82271328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371322"],"award-info":[{"award-number":["82371322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301661"],"award-info":[{"award-number":["82301661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024YFFK0314"],"award-info":[{"award-number":["2024YFFK0314"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent single subcortical infarction (RSSI) in lenticulostriate artery territories exhibits etiological heterogeneity. Misclassification risks persist due to overlapping neuroimaging features between cerebral small\u2010vessel disease\u2010related lacunar infarction (CSVD\u2010related LI) and branch atheromatous disease (BAD). We developed a nomogram that integrates retinal optical coherence tomography angiography (OCTA) metrics with infarct topography to improve etiological classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with RSSI were prospectively enrolled between December 2021 and December 2023. LASSO regression identified predictors for a logistic regression\u2013based nomogram. Performance was evaluated via concordance index (C\u2010index), calibration curves, and decision\u2010curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 127 RSSI patients (86 CSVD\u2010related LI, 41 BAD) were included. Three variables\u2014superficial vascular complex density, number of lesion slices, and proximal lesion location\u2014were retained in the final model. The nomogram achieved a C\u2010index of 0.84 (95% CI, 0.80\u20130.89) versus 0.68 for conventional imaging, with superior net benefit across clinical thresholds (AUC 0.84 vs. 0.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel nomogram combining OCTA\u2010derived retinal biomarkers with infarct topography improves differentiation of BAD from CSVD\u2010related LI in RSSI patients and may facilitate etiology\u2010driven clinical decision\u2010making. External validation is needed for clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70752","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:46:58Z","timestamp":1768823218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>OCTA<\/scp>\n                    \u2010Derived Retinal Biomarkers and Infarct Topography Improve Etiologic Classification of Recent Single Subcortical Infarction: A Nomogram Model"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-1535","authenticated-orcid":false,"given":"Shuai","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4694","authenticated-orcid":false,"given":"William 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