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The amplitude of low\u2010frequency fluctuations (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared between groups via voxel\u2010based analyses, while graph theory was used to assess brain network topology.\n                      <jats:italic>T<\/jats:italic>\n                      \u2010tests and multikernel support vector machine (MK\u2010SVM) were used to identify discriminative connectome features for classification.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with acromegaly exhibited lower Montreal Cognitive Assessment scores, increased ALFF in the default mode network regions, and decreased fALFF in the frontal\u2013parietal control network areas. ReHo was elevated in the visual network but reduced in the frontal\u2013parietal network. Disruptions were observed in key hub nodes within the default mode and visual networks. The MK\u2010SVM achieved 85.11% accuracy and 80.00% sensitivity in classifying patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with acromegaly exhibited altered brain function and network disruptions. These results offer novel insights into the mechanisms of excess GH in the brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70755","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:40:19Z","timestamp":1768819219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Brain Function and Network Topology in Patients With Acromegaly: Resting\u2010State\n                    <scp>fMRI<\/scp>\n                    Study of Networks Related to Cognitive and Emotional Processing"],"prefix":"10.1002","volume":"32","author":[{"given":"Zerui","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan 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