{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T11:09:53Z","timestamp":1771153793704,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>End\u2010stage renal disease (ESRD) is associated with working memory (WM) impairment. We assessed how structural connectivity (SC), functional connectivity (FC), and structural\u2013functional coupling (SFC) differ between pre\u2010dialysis ESRD (ESRDp), maintenance hemodialysis ESRD (ESRDm), and healthy controls (HCs), and how these changes relate to serum markers and WM performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>29 ESRDp, 29 ESRDm, and 46 HCs completed 0\u2010, 1\u2010, and 2\u2010back tasks, diffusion MRI, and fMRI. WM nodes were defined by overlaying a meta\u2010analytic map with the Harvard\u2013Oxford atlas. SC, FC, and regional SFC were computed among WM\u2010related regions. Group differences, correlations with serum markers, and mediation models were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ESRDp showed markedly lower n\u2010back accuracy, longer reaction time (RT), reduced frontoparietal SC, and widespread SFC reductions compared with ESRDm and HCs, whereas ESRDm exhibited near\u2010normal WM performance and partially restored SC\/SFC. Elevated urea and lower sodium in ESRDp were associated with weaker SC and altered SFC, which related to poorer accuracy and slower RT; SC and SFC significantly mediated these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ESRDp is characterized by disruption and decoupling of WM networks, while ESRDm is associated with partial network normalization. WM\u2010related SC and SFC combined with serum markers may help identify cognitive vulnerability in ESRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT03961724\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70761","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:22:16Z","timestamp":1768821736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Connectivity Disruption and Structural\u2013Functional Decoupling in Working Memory Networks Across Pre\u2010Dialysis and Maintenance Hemodialysis End\u2010Stage 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