{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:58:13Z","timestamp":1792519093160,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Alzheimer's Disease (AD) is a neurodegenerative condition with poorly understood mechanisms and few effective treatments. \u03b2\u2010asarone has shown potential in AD management, though its molecular actions require further clarification. This study investigates the mechanisms through which \u03b2\u2010asarone exerts its effects using both animal and cellular models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In vivo, the 3\u00d7Tg\u2010AD mice were administered \u03b2\u2010asarone for 8\u2009weeks. Learning and memory abilities were assessed via the Morris water maze and step\u2010down tests. Histomorphological examination, immunofluorescence, immunohistochemistry, ELISA, transmission electron microscopy, and Western blotting were employed to detect pathological changes, neuroinflammation, and protein expression of relevant signaling pathway molecules. In\u00a0vitro, A\u03b2 was used to culture BV\u20102 cells to mimic the brain microenvironment in Alzheimer's disease; changes in neuroinflammation, autophagy, and NLRP3 inflammasome\u2010related proteins were observed after treatment with \u03b2\u2010asarone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The administration of \u03b2\u2010asarone resulted in enhanced cognitive performance in 3\u00d7Tg\u2010AD mice, alongside a reduction in microglial apoptosis induced by A\u03b2. Additionally, \u03b2\u2010asarone diminished the accumulation of A\u03b2 and phosphorylated Tau, ultimately supporting neuronal survival. In both the hippocampal tissue and BV\u20102 cell models, treatment with \u03b2\u2010asarone led to a downregulation of neuroinflammatory markers and modulation of autophagy\u2010related proteins (Beclin\u20101, P62, ATG5, LC3\u2010II\/I), while concurrently suppressing components of the NLRP3 inflammasome (NLRP3, ASC, Caspase\u20101, cleaved Caspase\u20101). Notably, the autophagy inhibitor 3\u2010MA counteracted the inhibitory effects of \u03b2\u2010asarone on NLRP3 activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03b2\u2010Asarone attenuates AD\u2010related neuroinflammation by activating autophagy to inhibit NLRP3 inflammasome assembly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70771","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:36:34Z","timestamp":1770194194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u03b2\u2010Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing\n                    <scp>NLRP3<\/scp>\n                    Inflammasome Assembly"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-8021","authenticated-orcid":false,"given":"Zhiwei","family":"Xu","sequence":"first","affiliation":[{"name":"Jinhua Academy Zhejiang Chinese Medical University  Jinhua China"},{"name":"Second Clinical Medical School Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Xu","sequence":"additional","affiliation":[{"name":"Jinhua Academy Zhejiang Chinese Medical University  Jinhua China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"He","sequence":"additional","affiliation":[{"name":"Jinhua Academy Zhejiang Chinese Medical University  Jinhua China"},{"name":"School of Pharmaceutical Sciences Zhejiang Chinese Medical University  Hangzhou 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