{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:47:32Z","timestamp":1780994852617,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508002\uff1b2023YFC2508403"],"award-info":[{"award-number":["2023YFC2508002\uff1b2023YFC2508403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371168"],"award-info":[{"award-number":["82371168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020771","name":"Natural Science Foundation for Young Scientists of Shanxi Province","doi-asserted-by":"publisher","award":["82501420"],"award-info":[{"award-number":["82501420"]}],"id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Vestibular dysfunction is strongly linked to cognitive impairment and dementia risk, yet its underlying mechanisms remain unclear, hindering treatment development. As a primary physical therapy intervention, aerobic exercise improves cognitive dysfunction. Thus, we investigated its potential to reverse cognitive deficits after vestibular dysfunction and explored the neurobiological mechanisms involved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Behavioral experiments were conducted to assess the cognitive impairment induced by unilateral labyrinthectomy (UL). Immunofluorescence staining was performed to assess neural stem cell proliferation and newborn neuron maturation in the hippocampal dentate gyrus. Aerobic exercise was applied as an intervention to examine its effects on cognitive and neurogenic recovery. RNA sequencing followed by qRT\u2010PCR was used to characterize transcriptional changes. Pharmacological manipulation is applied to demonstrate the necessity and sufficiency of key candidate genes in mediating the exercise\u2010induced effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UL induced significant cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention reversed these impairments. Transcriptomic profiling showed that aerobic exercise normalized UL\u2010disrupted gene expression, with enrichment observed in MHC class I\/II\u2013related (H2\u2010K1, H2\u2010Eb1, CD74) and neurodevelopmental (Cntn5, Mid1) pathways. Pharmacological experiments established causality: inhibition of neuroinflammatory signaling with AZD1480 enhanced neurogenesis and improved cognition after UL, whereas LPS\u2010mediated activation of inflammation attenuated the beneficial effects of aerobic exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide a novel non\u2010pharmacological strategy for cognitive rehabilitation, as well as early cognitive screening and exercise rehabilitation intervention for patients with vestibular disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70773","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:50:17Z","timestamp":1770108617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhanghong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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