{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:02:26Z","timestamp":1773007346488,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011697"],"award-info":[{"award-number":["2024A1515011697"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Differentiating between sparsely granulated and densely granulated somatotroph tumors (SGSTs and DGSTs) currently relies on postoperative immunohistochemistry. This study aimed to evaluate whether triglyceride (TG), uric acid (UA), and their composite TG\u2013UA index [ln(TG\u2009\u00d7\u20091000\/UA)] could serve as preoperative indicators for distinguishing granulation subtypes of somatotroph tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter retrospective cohort study, 230 patients with somatotroph tumors were analyzed. Logistic regression and generalized additive models assessed associations and potential nonlinear associations between metabolic indicators and granulation subtypes. Predictive performance was compared between models using UA and TG separately and those using the TG\u2013UA index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SGSTs were associated with significantly higher TG, growth hormone, insulin\u2010like growth factor 1, and TG\u2013UA index values. The TG\u2013UA index remained an independent predictor of the SGST subtype (OR\u2009=\u20091.514,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Predictive performance was similar between models (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.108).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TG\u2013UA index is a promising noninvasive biomarker for identifying the SGST subtype in somatotroph tumors. Although limited by its retrospective design and lack of long\u2010term data, this study provides a foundation for future prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70774","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:10:14Z","timestamp":1770109814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study"],"prefix":"10.1002","volume":"32","author":[{"given":"Le","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou Guangdong China"},{"name":"School of Basic Medical Sciences, Guangdong Pharmaceutical University  Guangzhou Guangdong 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