{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:02:27Z","timestamp":1773007347123,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100954"],"award-info":[{"award-number":["32100954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270467"],"award-info":[{"award-number":["82270467"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence increasingly links environmental light exposure to the development of anxiety disorder. The rostral ventrolateral medulla (RVLM), a key brainstem center that regulates sympathetic outflow and blood pressure (BP), has been implicated in the autonomic dysregulation frequently observed in anxiety. High blood pressure is a recognized exacerbating factor for anxiety\u2010related pathology. Although aberrant projections from the central amygdala (CeA) to brainstem regions have been reported in multiple mood disorders, it remains unclear whether the CeA receives input from the RVLM and to what extent the RVLM's excitation influences anxiety symptoms induced by chronic light exposure (CL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed a chronic mild light (250\u2013300\u2009lx) for 4\u2009weeks to induce anxiety\u2010like behaviors in mice. Using a tail\u2010cuff system and ELISA assay, we assessed CL mice's BP and plasma catecholamine levels. Immunofluorescence was utilized to unravel the neuronal c\u2010fos expression in the RVLM and CeA. Combining retrograde virus tracing technology, chemogenetic and optogenetic manipulations in freely moving mice to examine the effects of regulating RVLM\u2010CeA pathway on anxiety\u2010like behaviors induced by chronic light.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Chronic light exposure in mice induces elevated blood pressure and elevated neuronal activity, which are more pronounced in the RVLM than in the CeA. Chemogenetic inhibition of RVLM neurons markedly attenuated CL\u2010induced anxiety\u2010like behaviors. Moreover, optogenetic inhibition of the RVLM\u2192CeA pathway reduced anxiety phenotypes in CL\u2010exposed mice, whereas optogenetic activation of this pathway in normal mice acutely triggered anxiety\u2010like behaviors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate that the enhanced excitatory signaling within the RVLM\u2192CeA circuit underlies the development of anxiety\u2010like behaviors induced by chronic light, revealing a novel mechanism by which the RVLM regulates light\u2010related affective dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70775","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:03:43Z","timestamp":1770361423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Rostral Ventrolateral Medulla Input to Central Amygdala Regulates Anxiety\u2010Like Behaviors in Mice for Chronic Light Exposure"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3311-1251","authenticated-orcid":false,"given":"Jia\u2010Ni","family":"Jing","sequence":"first","affiliation":[{"name":"Center of Cognition and Brain Science Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-0438","authenticated-orcid":false,"given":"Xing","family":"Tan","sequence":"additional","affiliation":[{"name":"Naval Medical Center Naval Medical University (Second Military Medical University)  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chou","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The 983rd Hospital of the Joint Logistics Support Force of PLA  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center of Cognition and Brain Science Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Fan","sequence":"additional","affiliation":[{"name":"Center of Cognition and Brain Science Beijing Institute of Basic Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-6576","authenticated-orcid":false,"given":"Wei\u2010Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Naval Medical Center Naval Medical University (Second Military Medical University)  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/07067437241303031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01488-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.07.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.70"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-00568-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.10.039"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.04.039"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020343"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14915"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3743"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2016.tb00711.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114546"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102918"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.650"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.153775"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04023.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab031"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03178-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0068-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.122598"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00248"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05606-3"},{"key":"e_1_2_11_24_1","first-page":"155","article-title":"Some Assessments of the Amygdala Role in Suprahypothalamic Neuroendocrine Regulation: A Minireview","volume":"41","author":"Talarovicova A.","year":"2007","journal-title":"Endocrine Regulations"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00894-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf4198"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113766"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010180107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215588052"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2019.04.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.05.028"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2016.04.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.06.018"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136917"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05936"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13864"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf4651"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146622"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14188"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3945"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5803"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.025"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.02.008"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0384-15.2015"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.009"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29155-1"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69333"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.119618"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00139"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.015"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-19-000001"},{"key":"e_1_2_11_52_1","first-page":"7","article-title":"The Impact of Modulated, Colored Light on the Autonomic Nervous System","volume":"27","author":"Ross M. J.","year":"2013","journal-title":"Advances in Mind\u2010Body Medicine"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14080802"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025000919468"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0567-20.2020"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70775","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:04Z","timestamp":1772999824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cns.70775"],"URL":"https:\/\/doi.org\/10.1002\/cns.70775","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70775"}}