{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:15:34Z","timestamp":1792268134918,"version":"4.4.0"},"reference-count":81,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871016"],"award-info":[{"award-number":["81871016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M640306"],"award-info":[{"award-number":["2018M640306"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH\u2010Q21132"],"award-info":[{"award-number":["LBH\u2010Q21132"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBH\u2010Q20045"],"award-info":[{"award-number":["LBH\u2010Q20045"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epilepsy represents a prevalent neurological disorder. Currently, ferroptosis has been reported to be intricately linked to epilepsy onset and progression. Dihydroartemisinin (DHA) can inhibit the level of ferroptosis in various diseases. Therefore, the present study investigated whether DHA could inhibit seizures and display neuroprotective impacts by impeding ferroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the KA\u2010induced epileptic mouse model, the effects of DHA on epileptic behavior, cognitive function, and hippocampal neuronal damage were observed. Using both in\u00a0vivo and in\u00a0vitro models, the impact of DHA on neuronal injury and ferroptosis\u2010related markers was investigated. Techniques including molecular docking, Western Blot, immunofluorescence, and CHIP\u2010qPCR\u00a0were utilized to analyze the regulatory mechanism of DHA on ferroptosis in epilepsy. Finally, brain tissue samples from patients with temporal lobe epilepsy (TLE) were collected to validate the expression of ferroptosis\u2010related markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our experimental results showed that DHA attenuated seizures, hippocampal neuronal damage, and memory and learning deficits in epileptic mice. Moreover, DHA inhibited ferroptosis by activating solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) expression in\u00a0vivo and in\u00a0vitro. Subsequently, we found that DHA activated SIRT1 expression in the mouse hippocampus, leading to a decrease in the acetylation level of forkhead box O1 (FOXO1), thereby increasing the transcriptional activity of SLC7A11. Finally, our findings provide preliminary clinical support for the association between ferroptosis and TLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, our findings indicate that DHA may have antiepileptic and neuroprotective benefits by suppressing ferroptosis through the SIRT1\/FOXO1\/SLC7A11\/GPX4 signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70798","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:30:31Z","timestamp":1771597831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the\n                    <scp>SIRT1<\/scp>\n                    \/\n                    <scp>FOXO1<\/scp>\n                    \/\n                    <scp>SLC7A11<\/scp>\n                    \/\n                    <scp>GPX4<\/scp>\n                    Pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhipeng","family":"You","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-431X","authenticated-orcid":false,"given":"Cong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Fourth Affiliated Hospital of Harbin Medical University  Harbin 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