{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:33Z","timestamp":1786977513397,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471339"],"award-info":[{"award-number":["82471339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82330039"],"award-info":[{"award-number":["82330039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571484"],"award-info":[{"award-number":["82571484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive impairment is a critical yet poorly understood complication of brain arteriovenous malformations (bAVM). While traditionally attributed to hemodynamic \u201csteal\u201d or focal tissue destruction, it remains unclear whether cognitive variability correlates with gross structural pathology or broader network disruption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited consecutive patients with unruptured bAVM at Huashan Hospital and matched healthy controls (2017\u20132020). We integrated lesion frequency mapping, surface\u2010based morphometry, and Network Diffusion Modeling (NDM) to dissect the structure\u2013function relationship in a cohort of bAVM patients compared to matched controls. We systematically evaluated the predictive value of three distinct damage metrics\u2014gross lesion load, cortical morphological remodeling, and white matter structural connectivity\u2014on global and domain\u2010specific cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with bAVM exhibited significantly reduced global efficiency in structural networks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), which was a stronger predictor of cognitive decline than lesion volume. In contrast, global functional network topology was largely preserved. Although local functional reorganization was observed, characterized by increased inter\u2010hemispheric synchronization, these adaptations did not prevent cognitive deficits. Notably, increased structure\u2013function decoupling within high\u2010order association networks (including frontoparietal and ventral attention systems) was significantly associated with executive and memory impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitive dysfunction in bAVM represents a disconnection syndrome caused by the disruption of long\u2010range white matter tracts rather than local cortical pathology. The dissociation between structural damage and functional compensation highlights the limitations of conventional volumetric assessment. Preoperative connectome mapping, particularly of white matter integrity, may improve risk stratification and functional preservation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70819","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:17:56Z","timestamp":1773238676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Network Disconnection Syndrome in Unruptured Brain Arteriovenous Malformations: A Multimodal Connectome Study"],"prefix":"10.1002","volume":"32","author":[{"given":"Xuchen","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojing","family":"Duan","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0500-0989","authenticated-orcid":false,"given":"Hongfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Lin","sequence":"additional","affiliation":[{"name":"Huashan Institute of Medicine, Huashan Hospital Fudan University  Shanghai China"},{"name":"School of Data Science Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-2434","authenticated-orcid":false,"given":"Kai","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-7476","authenticated-orcid":false,"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Huashan Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"National Center for Neurological Disorders  Shanghai China"},{"name":"Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration  Shanghai China"},{"name":"Neurosurgical Institute Fudan University  Shanghai China"},{"name":"Shanghai Clinical Medical Center of Neurosurgery  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30181-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62302-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3200"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa363"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.12.JNS181883"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2233010792"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.3.0477"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200204000-00002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.2.JNS091595"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1568045"},{"key":"e_1_2_11_12_1","first-page":"294","article-title":"Effect of Focal and Nonfocal Cerebral Lesions on Functional Connectivity Studied With MR Imaging","volume":"22","author":"Quigley M.","year":"2001","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18933"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS14629"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae315"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.040"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010023\u201000718\u20105"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2021.0850"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.092"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116137"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2022.1206"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.2.FOCUS09317"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12765-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.05.054"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29770-y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1065245"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910397107"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011400"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)03800-2"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1619226"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70602"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:22:32Z","timestamp":1777562552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/cns.70819"],"URL":"https:\/\/doi.org\/10.1002\/cns.70819","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70819"}}