{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:24:14Z","timestamp":1782415454486,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"am","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204357"],"award-info":[{"award-number":["82204357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803505"],"award-info":[{"award-number":["81803505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) lacks effective disease\u2010modifying therapies, despite mitochondrial dysfunction being a key pathogenic factor. This study aimed to identify novel regulators of mitochondrial dynamics and explore their therapeutic relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Transcriptomic analysis was conducted on the substantia nigra (SN) of 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP)\u2010induced PD mice. SN\u2010specific lentiviral knockdown or overexpression of nucleoside diphosphate kinase 3 (NME3) was performed in mice. Motor behavior, dopaminergic neuron survival, mitochondrial ultrastructure, and reactive oxygen species (ROS) levels were assessed. Mitochondrial fission was pharmacologically inhibited using the Drp1 inhibitor Mdivi\u20101.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RNA sequencing revealed a marked reduction of\n                      <jats:italic>Nme3<\/jats:italic>\n                      in the SN of MPTP\u2010treated mice.\n                      <jats:italic>Nme3<\/jats:italic>\n                      knockdown in healthy mice induced PD\u2010like motor deficits and dopaminergic neurodegeneration, mimicking the MPTP model. Mechanistically, NME3 deficiency disrupted mitochondrial fission\u2010fusion balance, causing abnormal mitochondrial morphology, excessive ROS production, and neuronal injury. Mdivi\u20101 treatment significantly alleviated mitochondrial dysfunction and neurotoxicity. Conversely, SN\u2010specific\n                      <jats:italic>Nme3<\/jats:italic>\n                      overexpression in MPTP\u2010treated mice improved motor performance and preserved dopaminergic neurons by suppressing pathological mitochondrial fission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NME3 is a previously unrecognized regulator of mitochondrial dynamics and a critical contributor to PD pathogenesis. Restoring mitochondrial fission\u2010fusion balance through genetic or pharmacological approaches provides neuroprotection, highlighting NME3 as a promising target for disease\u2010modifying PD therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70822","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:27:46Z","timestamp":1773116866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting\n                    <scp>NME3<\/scp>\n                    to Restore Mitochondrial Fission\u2010Fusion Balance Defines a Novel Disease\u2010Modifying Strategy for Parkinson's Disease"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4315-0351","authenticated-orcid":false,"given":"Chen","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Hospital of Jiangsu University Jiangsu University  Zhenjiang Jiangsu China"},{"name":"College of Pharmacy Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Qi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Hospital of Jiangsu University Jiangsu University  Zhenjiang Jiangsu China"},{"name":"College of Pharmacy Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen\u2010Han","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Fan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Hospital of Jiangsu University Jiangsu University  Zhenjiang Jiangsu China"},{"name":"College of Pharmacy Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Affiliated Hospital of Jiangsu University Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6493-1467","authenticated-orcid":false,"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080952"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.07.033"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar6606"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.09.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-9912.385949"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.03.030"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-9912.385940"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114645"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-020-00636-w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/2045-9912.385945"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04059-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.36.20220001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503579"},{"issue":"8","key":"e_1_2_11_15_1","article-title":"Gene\u2010Based Therapeutics for Parkinson's Disease","volume":"10","author":"Shalaby K. 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