{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:38:52Z","timestamp":1792539532417,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Temazepam has not been adequately investigated for its long\u2010term safety profile in broad patient populations. This study aimed to characterize temazepam's real\u2010world long\u2010term safety profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Reports of adverse events from Q1 2006 to Q4 2025 comprising temazepam were collected from the FAERS database. Data were analyzed using disproportionality methods including the proportional reporting ratio (PRR), the reporting odds ratio (ROR), the multi\u2010item gamma poisson shrinker (MGPS), and the Bayesian confidence propagation neural network (BCPNN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2788 adverse event reports associated with temazepam were retrieved. The most frequently reported events were drug ineffective, eye irritation, and toxicity to various agents. We also detected numerous ocular risk signals absent from the product label, together with potential abuse signals. Furthermore, our study identified several behavioral risk signals such as abnormal behavior, aggression, and amnesia and parasomnias\u2010related adverse events like nightmare and somnambulism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A comprehensive analysis of the large scale real world FAERS database was performed in this study identifying an extensive spectrum of adverse events associated with temazepam. Our study confirmed established risks and detected potential novel signals including ocular toxicities (e.g., eye irritation, intraocular pressure increased, glaucoma, eye inflammation, and photophobia) as well as neuro behavioral adverse outcomes such as aggression, amnesia and parasomnias (e.g., nightmare and somnambulism). These findings provide compelling support for temazepam clinical monitoring and risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70836","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:35:01Z","timestamp":1774254901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Real\u2010World Safety Profile of Temazepam: A 20\u2010Year Pharmacovigilance Analysis Based on the Large\u2010Scale\n                    <scp>FAERS<\/scp>\n                    Database"],"prefix":"10.1002","volume":"32","author":[{"given":"Zujun","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Heyuan People's Hospital  Heyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, the Sixth People's Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9626-7086","authenticated-orcid":false,"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Dazhou Central Hospital  Dazhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-12112-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215324"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.325686"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S563616"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2024-000952"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.02.021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8986"},{"issue":"11","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.71085","article-title":"Long\u2010Term Use of Benzodiazepines and Related Drugs in Persons With Major Depressive Disorder","volume":"15","author":"Laitinen H.","year":"2025","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33929"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2021.0054"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.159351"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02213-x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.19029"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa260"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1461166"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.19067"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70176"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa169"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13608"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0569-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2025.2494804"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2334828"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-23920-9"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01728-8"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0348-19.2020"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S550775"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43215"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212905"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291724002046"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/15389588.2024.2358093"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00801-9"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-025-00627-0"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-023-03090-2"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2025.1639890"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2025.110375"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2022.108929"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01342-6"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2025.2548524"},{"key":"e_1_2_12_40_1","article-title":"Trends in Psychotropic Medication Use, Polypharmacy, and Potential Major Drug\u2010Drug Interactions Among US Youth","author":"Meng L. C.","year":"2025","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint13040059"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4850"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.893015"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132947"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20210017"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-025-01249-6"},{"issue":"11","key":"e_1_2_12_47_1","article-title":"Ocular Adverse Effects of Common Psychotropic Agents: A Review","volume":"24","author":"Razeghinejad M. R.","year":"2010","journal-title":"CNS Drugs"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTO.S355091"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2025.04.003"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-020-00790-w"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_2804_24"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2019.04.013"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-020-00914-7"},{"issue":"2","key":"e_1_2_12_54_1","first-page":"99","article-title":"Ocular Toxicity of Psychotropic Medications in a Tertiary Hospital in Lagos, Nigeria","volume":"68","author":"Balogun M. M.","year":"2024","journal-title":"Romanian Journal of Ophthalmology"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2024.100192"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98689-z"},{"key":"e_1_2_12_57_1","first-page":"1","article-title":"Biological Sex Differences in Pharmacokinetics and Adverse Drug Reactions","volume":"399","author":"Aljohmani A.","year":"2025","journal-title":"Naunyn\u2010Schmiedeberg's Archives of Pharmacology"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12100690"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:22:24Z","timestamp":1777562544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/cns.70836"],"URL":"https:\/\/doi.org\/10.1002\/cns.70836","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70836"}}