{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:11:37Z","timestamp":1780913497751,"version":"3.54.1"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873754"],"award-info":[{"award-number":["81873754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371333"],"award-info":[{"award-number":["82371333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ\u2010LZX0044"],"award-info":[{"award-number":["CSTB2025NSCQ\u2010LZX0044"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016834","name":"Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["YXGD202451"],"award-info":[{"award-number":["YXGD202451"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify key environment\u2010sensitive inflammatory factors and clarify their pathogenic mechanisms in severe secondary brain injury after intracerebral hemorrhage (ICH) in high\u2010altitude migrants\u2014addressing the critical gap that elevated hemoglobin alone cannot fully explain the underlying pathogenesis and investigating chronic inflammation as a key pathogenic driver.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Olink proteomics profiling was performed in 66 high\u2010altitude migrants and 22 plain\u2010resident controls to identify differentially expressed inflammatory factors. Rat high\u2010altitude ICH models were subsequently established and treated with AAV\u2010CCL2, a CCL2\u2010neutralizing antibody, recombinant CCL2, and a CCR2 inhibitor, and the results were validated through transcriptomic and multidimensional methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCL2 was the most significantly upregulated environmentally sensitive inflammatory factor and was weakly correlated with hemoglobin levels. High\u2010altitude rats had higher levels of post\u2010ICH CCL2, which was associated with severe blood\u2013brain barrier (BBB) disruption; CCR2 blockade abolished CCL2\u2010induced BBB damage and neuroinflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CCL2 plays an important role in secondary injury after high\u2010altitude ICH, mainly by amplifying inflammation and exacerbating damage via the CCL2\u2013CCR2\u2013NF\u2010\u03baB pathway and may serve as a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70868","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:41:56Z","timestamp":1775565716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Olink Proteomics Reveals\n                    <scp>CCL2<\/scp>\n                    Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High\u2010Altitude Migrants Via\n                    <scp>CCR2<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    \u2010Mediated Blood\u2013Brain Barrier Disruption"],"prefix":"10.1002","volume":"32","author":[{"given":"Rongsu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Department of Neurosurgery General Hospital of Tibet Military Command  Lhasa China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Department of Information, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Dai","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital Third Military 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