{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:11:38Z","timestamp":1780913498792,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","award":["The Robert M. Epstein Professorship endowment"],"award-info":[{"award-number":["The Robert M. Epstein Professorship endowment"]}],"id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS099118"],"award-info":[{"award-number":["R01 NS099118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018088","name":"School of Medicine, University of Virginia","doi-asserted-by":"publisher","award":["Department of Anesthesiology"],"award-info":[{"award-number":["Department of Anesthesiology"]}],"id":[{"id":"10.13039\/100018088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity and associated metabolic disturbance are associated with worse outcomes after brain ischemia. Cerebrovascular remodeling mediated by matrix metalloproteinase 9 (MMP\u20109) may contribute to this poor outcome. A disintegrin and metalloproteinase\u20107 (ADAMTS\u20107) has been shown to regulate vascular remodeling in peripheral vessels. This study was designed to determine the role of ADAMTS\u20107 in regulating MMP\u20109 activity, cerebrovascular remodeling and neurological outcomes in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six\u2010week\u2010old CD\u20101 male mice were fed regular diet (RD) or high fat diet (HFD) for 10\u2009weeks before they had left middle cerebral arterial occlusion (MCAO) for 1.5\u2009h. Their brains were harvested for Western blotting, immunostaining or cerebral vascular casting. Lentiviral particles containing shRNA targeting ADAMTS\u20107 mRNA or scramble shRNA were injected intracerebroventricularly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HFD feeding increased ADAMTS\u20107 and MMP\u20109 activity, reduced middle cerebral arterial root diameter, and worsened neurological outcomes after the MCAO. Silencing ADAMTS\u20107 attenuated these HFD\u2010induced effects. ADAMTS\u20107 was expressed in the neurons, astrocytes, oligodendrocytes, and blood vessels in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HFD increased ADAMTS\u20107 to lead to MMP\u20109 activation, which then induces cerebrovascular remodeling and poor neurological outcomes after brain ischemia. ADAMTS\u20107 is expressed in multiple cell types in the brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70877","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:47:03Z","timestamp":1776052023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ADAMTS<\/scp>\n                    \u20107 Increase Contributes to Worsened Neurological Outcome in Mice on High Fat Diet"],"prefix":"10.1002","volume":"32","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-5047","authenticated-orcid":false,"given":"Zhiyi","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a993"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2279"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.665190"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22539"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu154"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201003573\u20104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.123.322737"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014072"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314913"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010023\u201001648\u20101"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001291\u2010y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.5.1172"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010017\u20100826\u20106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003007\u20106"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010662\u201009525\u20106_6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.04.018"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.12.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251313723"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319163"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31130"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909790031157"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00095.2018"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25555"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102013\u2010203561"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/801546"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.57218"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1431"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:37:59Z","timestamp":1780911479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cns.70877"],"URL":"https:\/\/doi.org\/10.1002\/cns.70877","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70877"}}