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The primary outcomes included stroke and moderate\u2010to\u2010severe bleeding, whereas secondary outcomes comprised composite vascular events, poor functional outcomes, and any bleeding within 90\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 6100 patients, 4038 were without T2DM, 404 had a newly diagnosed T2DM, and 1658 had a history of T2DM. No significant risk reduction of stroke was observed with immediate versus delayed statin therapies across glycemic subgroups (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.29). Compared to delayed\u2010intensive statin, immediate\u2010intensive statin treatment was associated with reduced risk of poor functional outcome in non\u2010T2DM patients (adjusted relative risk 0.71, 95% CI 0.57\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), but no benefit in those with newly diagnosed T2DM or those with a history of T2DM (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.003). There was no glycemic status by treatment interaction for risk of bleeding or composite vascular event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients without T2DM derived greater benefit in functional outcomes from immediate\u2010intensive statin after ischemic stroke than those with T2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70882","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:03:10Z","timestamp":1777284190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycemic Status and Effect of Immediate Intensive Statin on Mild Ischemic Stroke: A Subgroup Analysis of the\n                    <scp>INSPIRES<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-6419","authenticated-orcid":false,"given":"Lingling","family":"Jiang","sequence":"first","affiliation":[{"name":"China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2681-7180","authenticated-orcid":false,"given":"Zihao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-186X","authenticated-orcid":false,"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"National Center for Neurological 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