{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:38:06Z","timestamp":1792881486300,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia with Lewy bodies (DLB) frequently coexists with cerebrovascular injury and Alzheimer's\u2010related pathology, yet accessible in\u00a0vivo markers of these processes remain limited. The retinal microvasculature shares structural and physiological characteristics with cerebral small vessels and may provide a non\u2010invasive window into neurovascular and neurodegenerative pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, 32 individuals with DLB and 31 age\u2010matched cognitively unimpaired controls (CU) underwent swept\u2010source optical coherence tomography angiography (OCTA), brain MRI, and plasma biomarker assessment. Retinal vessel densities of the superficial vascular complex (SVC), deep vascular complex (DVC), and choriocapillaris (CC) were quantified. Plasma amyloid\u2010\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , phosphorylated tau\u2010217 (p\u2010tau217), and glial fibrillary acidic protein were measured. Cerebral small vessel disease (SVD) burden and white matter hyperintensity (WMH) volumes were derived from MRI. Associations with cognition and mediation by WMH burden were evaluated using generalized estimating equations and bootstrapped mediation analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with CU, individuals with DLB exhibited significantly reduced SVC, DVC, and CC vessel densities (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lower retinal vessel densities were associated with higher plasma amyloid burden and elevated p\u2010tau217, as well as greater SVD burden and periventricular WMH volume. APOE \u03b54 carriers demonstrated more pronounced retinal microvascular impairment, higher WMH burden, and elevated p\u2010tau217 levels than non\u2010carriers. Reduced SVC density was associated with worse global cognition, and this relationship was partially mediated by periventricular WMH volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Retinal microvascular impairment measured by OCTA is closely linked to Alzheimer's\u2010related plasma biomarkers, SVD, and cognitive decline in DLB. These findings support retinal OCTA as a scalable, non\u2010invasive biomarker reflecting convergent neurodegenerative and vascular pathology in DLB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70891","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:45:13Z","timestamp":1776782713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retinal Microvascular Dysfunction Reflects Vascular and Alzheimer's\u2010Related Pathology in Dementia With Lewy Bodies"],"prefix":"10.1002","volume":"32","author":[{"given":"Qiuling","family":"Tong","sequence":"first","affiliation":[{"name":"Neurology Department The First Affiliated Hospital of Wenzhou Medical University  Wenzhou, Ouhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4694","authenticated-orcid":false,"given":"William 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