{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:11:46Z","timestamp":1780913506328,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071234"],"award-info":[{"award-number":["82071234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170836"],"award-info":[{"award-number":["82170836"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31400947"],"award-info":[{"award-number":["31400947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this study was to explore the molecular mechanism of circRNA mediated colonic hypersensitivity in rats with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Intraperitoneal injection of streptozocin female rats was used to induce Type 1 Diabetes Mellitus. A combination of molecular biology and behavioral approaches was used to investigate the role of circRbfox1 in the pathogenesis of colonic hypersensitivity in diabetic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A new circular RNA\u2010Rbfox1, derived from the host gene encoding RNA\u2010Binding Protein Fox1, as a mechanism of visceral pain is identified. We confirmed that circRbfox1 remarkably upregulated in T13\u2010L2 dorsal root ganglions in rats with diabetes, and could interact with the RNA\u2010binding protein HuC to promote its transition from the cytosol into the nucleus to promote the translation level of RBFOX1. In addition, the increased expression of Rbfox1 could further promote colonic hypersensitivity in diabetic rats by regulating the expression of Cav1.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We conclude that circRbfox1 serves as pain regulator in diabetic colonic hypersensitivity and provides a potential therapeutic target in clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70896","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:43:42Z","timestamp":1777387422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CircRbfox1<\/scp>\n                    Contributes to Colonic Hypersensitivity in Rats With Diabetes by Altering\n                    <scp>HuC<\/scp>\n                    Subcellular Localization to Regulate\n                    <scp>RBFOX1<\/scp>\n                    Expression"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9641-553X","authenticated-orcid":false,"given":"Shiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"},{"name":"Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-999X","authenticated-orcid":false,"given":"Ji","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2201-932X","authenticated-orcid":false,"given":"Chendong","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7461-8815","authenticated-orcid":false,"given":"Yilian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1015-3273","authenticated-orcid":false,"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3907-7513","authenticated-orcid":false,"given":"Yajing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Soochow University  Suzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-5532","authenticated-orcid":false,"given":"Shufen","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow University  Suzhou P. 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