{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:11:40Z","timestamp":1780913500261,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term outcomes after endovascular treatment (EVT) in acute basilar artery occlusion (BAO) vary substantially, yet metabolic correlates remain incompletely characterized. This study evaluated whether the triglyceride\u2013glucose (TyG) index and TyG\u2013body mass index (TyG\u2010BMI) are associated with 1\u2010year functional status and mortality after EVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center registry with prospective data collection was retrospectively analyzed. Consecutive acute BAO patients undergoing EVT within 24\u2009h (December 2012\u2013September 2024) were included. Unfavorable functional outcome at 1\u2009year was defined as modified Rankin Scale (mRS) 4\u20136; 1\u2010year all\u2010cause mortality was also assessed. Multivariable logistic regression was applied, with receiver operating characteristic analyses and prespecified subgroup analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final cohort comprised 298 patients (median age 62\u2009years; 78.5% male), among whom 165 (55.4%) had an unfavorable 1\u2010year outcome and 109 (36.6%) died. After adjustment, each 1\u2010SD increase in TyG and TyG\u2010BMI corresponded to higher odds of unfavorable outcome (TyG OR 1.69, 95% CI 1.25\u20132.30; TyG\u2010BMI OR 1.46, 95% CI 1.10\u20131.96) as well as mortality (TyG OR 1.44, 95% CI 1.09\u20131.90; TyG\u2010BMI OR 1.61, 95% CI 1.23\u20132.12). Discrimination was modest and similar between indices. A significant sex interaction was observed for TyG\u2010BMI and mortality (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction\u2009=\u20090.03), with an association in men only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In EVT\u2010treated acute BAO, TyG and TyG\u2010BMI may help identify EVT\u2010treated acute BAO patients at higher risk of poor 1\u2010year outcome and death. The mortality risk associated with TyG\u2010BMI was modified by sex, with an effect confined to men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70898","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:53:59Z","timestamp":1776945239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the Triglyceride\u2013Glucose (\n                    <scp>TyG<\/scp>\n                    ) Index and\n                    <scp>TyG<\/scp>\n                    \u2010\n                    <scp>BMI<\/scp>\n                    With 1\u2010Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion"],"prefix":"10.1002","volume":"32","author":[{"given":"Qiuting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-6394","authenticated-orcid":false,"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-9126","authenticated-orcid":false,"given":"Longfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3390-3284","authenticated-orcid":false,"given":"Liqun","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2744","authenticated-orcid":false,"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-1936","authenticated-orcid":false,"given":"Chuanhui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00483-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01820-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00295-1"},{"key":"e_1_2_11_5_1","article-title":"Atherosclerosis and Insulin Resistance: Is There a Link Between Them?","volume":"13","author":"Brie A. 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