{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:14:15Z","timestamp":1779804855294,"version":"3.53.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82394434"],"award-info":[{"award-number":["82394434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62333002"],"award-info":[{"award-number":["62333002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate alterations in basal forebrain (BF) subregional functional connectivity (FC), cerebral glucose metabolism, and their spatial correspondence with atlas\u2010based neurotransmitter distributions in Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two A\u03b2\u2010PET\u2010positive AD patients and forty\u2010one matched healthy controls (HC) underwent simultaneous PET\/MRI. We analyzed resting\u2010state FC of BF subregions (Ch1\u20103, Ch4) and measured cerebral\u00a0glucose metabolism using\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET standardized uptake value ratio (SUVR). Spatial correlations with neurotransmitter maps were assessed using the JuSpace toolbox.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with HC, AD patients showed decreased FC between the left Ch4 and hippocampus\/posterior cingulate gyrus, and increased FC between the right Ch4 and precentral\/postcentral gyrus. Additionally, AD patients showed increased FC between the left Ch1\u20103 and superior temporal gyrus\/insula, decreased FC between the right Ch1\u20103 and the orbitofrontal gyrus, and increased FC between the right Ch1\u20103 and the left temporal lobe (voxel\u2010level\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, cluster\u2010level\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, GRF correction). These FC changes were spatially correlated with serotonergic (5HT1a, 5HT4, SERT) and dopaminergic (D1, D2, DAT) receptor distributions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, FDR corrected). Widespread cerebral hypometabolism in temporoparietal and frontal regions was spatially correlated with serotonin, dopamine, GABA, glutamate, and kappa\u2010opioid systems (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, FDR corrected).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The FC of BF and cerebral metabolic changes in AD show distinct spatial correspondence with specific neurotransmitter systems, highlighting the crucial involvement of serotonin and dopamine in AD pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70901","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:05:31Z","timestamp":1778321131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correspondence of Basal Forebrain Resting\u2010State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2058-2535","authenticated-orcid":false,"given":"Yujie","family":"He","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1675-5606","authenticated-orcid":false,"given":"Zhigeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3921","authenticated-orcid":false,"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics  Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.43"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001678\u2010x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100315"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010023\u201000677\u2010x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105192"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac093"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105393"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010024\u201006862\u2010z"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51176"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2024.108785"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180268"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.671351"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14038"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010017\u20103790\u20105"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101558"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043841"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230570"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl2675"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115218"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000925\u20101"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12776"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adk1822"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR\u2010D\u201024\u201000230"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101865"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2025.01.030"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14552"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25244"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2024.103921"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.240111"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106527"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010023\u201001943\u20101"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010025\u201007485\u20108"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201002988\u20107"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010020\u201004752\u20108"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010016\u20109299\u20104"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24417"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.055"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318288a8dd"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209626"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2024.106677"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053148\u2010x"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20883"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1037347"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120393"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001041\u20104"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102240"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010018\u20104030\u20103"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001893\u20106"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.70901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.70901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:57:45Z","timestamp":1779803865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.70901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cns.70901"],"URL":"https:\/\/doi.org\/10.1002\/cns.70901","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70901"}}