{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:28:08Z","timestamp":1790954888027,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602603"],"award-info":[{"award-number":["2022YFC3602603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this randomized, double\u2010blind, sham\u2010controlled trial, we explored whether high\u2010intensity transcranial alternating current stimulation (Hi\u2010tACS), as an add\u2010on to multidisciplinary intensive rehabilitation therapy (MIRT), could yield more durable quality of life (QoL) improvements than MIRT alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients with Parkinson's disease (PwP) (Hoehn and Yahr stages 1\u20133, aged 45\u201370) were assigned (1:1) to receive 10\u2009days of MIRT with either twice\u2010daily Hi\u2010tACS (15\u2009mA, 77.5\u2009Hz, 40\u2009min\/session) or sham stimulation. The primary outcome was the longitudinal change in the 39\u2010item Parkinson's Disease Questionnaire (PDQ\u201039) total score from baseline to 4, 12, and 24\u2009weeks after intervention. Secondary outcomes included changes in motor and non\u2010motor symptom scales. Adverse events were monitored throughout the intervention period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Generalized estimating equation analysis revealed a significant group\u2010by\u2010time interaction for PDQ\u201039 total scores (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>group\u2009\u00d7\u2009time<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.008). The Hi\u2010tACS+MIRT group demonstrated significantly greater reductions in PDQ\u201039 scores than the sham\u2010Hi\u2010tACS+MIRT group at 4\u2009weeks (T2: effect size\u2009=\u20090.68, 95% CI: 0.14\u20131.21;\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>FDR<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.009), 12\u2009weeks (T3: effect size\u2009=\u20091.43, 95% CI: 0.80\u20132.05;\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>FDR<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.003), and 24\u2009weeks (T4: effect size\u2009=\u20091.26, 95% CI: 0.65\u20131.85;\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>FDR<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009&lt;\u20090.001). In addition, the Hi\u2010tACS+MIRT group exhibited superior improvements in depression and apathy. Adverse events were mild and infrequent, with no serious adverse events reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This trial demonstrated that the Hi\u2010tACS add\u2010on to MIRT could maintain long\u2010term improvements in QoL and improve non\u2010motor symptoms for PwP, providing a new strategy for PwP rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70909","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:26:34Z","timestamp":1777357594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High\u2010Intensity Alternating Current Stimulation as an Add\u2010On to Multidisciplinary Intensive Rehabilitation for Parkinson's Disease: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"32","author":[{"given":"Ting\u2010ting","family":"Hou","sequence":"first","affiliation":[{"name":"Beijing Rehabilitation Medicine Academy Capital Medical University  Beijing China"},{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6503-9442","authenticated-orcid":false,"given":"Hong\u2010yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Rehabilitation Medicine Academy Capital Medical University  Beijing China"},{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010ke","family":"Chen","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Rehabilitation Medicine Academy Capital Medical University  Beijing China"},{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui\u2010ping","family":"Xue","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5805-0879","authenticated-orcid":false,"given":"Qiao\u2010xia","family":"Zhen","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010jiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing 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Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-1795","authenticated-orcid":false,"given":"Cui","family":"Liu","sequence":"additional","affiliation":[{"name":"Parkinson Medical Center, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010ping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Rehabilitation Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Peking University Clinical Research Institute Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center 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