{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:14:03Z","timestamp":1779804843800,"version":"3.53.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the clinical, radiological, and prognostic characteristics of autoimmune cortical encephalitis associated with different autoantibodies in Chinese adults, and to compare the features of myelin oligodendrocyte glycoprotein antibody\u2013associated cerebral cortical encephalitis (MOG\u2010CCE) with antibody\u2010negative and non\u2010MOG antibody\u2010positive autoimmune cortical encephalitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted on 120 adult patients diagnosed with autoimmune cortical encephalitis at the Second Xiangya Hospital, Central South University, from 2014 to 2024. Patients were divided into three subgroups: the antibody\u2010negative group, the non\u2010MOG antibody\u2010positive group, and the MOG\u2010CCE group. Clinical, radiological, and therapeutic characteristics were analyzed, and logistic regression was performed to identify predictors of poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MOG\u2010CCE accounted for 18.3% of all autoimmune cortical encephalitis cases. Compared with other subtypes, MOG\u2010CCE was characterized by seizure\u2010dominant clinical presentation and unilateral cortical MRI lesions. Patients with MOG\u2010CCE responded favorably to immunotherapy and exhibited lower recurrence and disability rates. In contrast, antibody\u2010negative and non\u2010MOG antibody\u2010positive autoimmune cortical encephalitis showed more severe neuropsychiatric symptoms and poorer outcomes. A higher peak mRS score was the strongest independent predictor of long\u2010term disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MOG\u2010CCE represents a distinct clinical phenotype within autoimmune cortical encephalitis, with favorable immunotherapy responsiveness and prognosis. Antibody profiling aids in disease classification and prognostic evaluation. Prospective multicenter studies are warranted to elucidate underlying mechanisms and refine individualized therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70915","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:10:09Z","timestamp":1778076609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myelin Oligodendrocyte Glycoprotein Antibody\u2010Associated Cerebral Cortical Encephalitis: A Comparative Study With Antibody\u2010Negative and Non\u2010\n                    <scp>MOG<\/scp>\n                    Antibody\u2010Positive Cortical Encephalitis in Chinese Adults"],"prefix":"10.1002","volume":"32","author":[{"given":"Qing","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Clinical Medical Research Center for Stroke Prevention and Treatment of Hunan Province, Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Clinical Medical Research Center for Stroke Prevention and Treatment of Hunan Province, Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  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of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-0242","authenticated-orcid":false,"given":"Yuwei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Clinical Medical Research Center for Stroke Prevention and Treatment of Hunan Province, Department of Neurology, Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Second Xiangya Hospital Central South University  Changsha Hunan 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