{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:14:34Z","timestamp":1789017274690,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260388"],"award-info":[{"award-number":["82260388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260378"],"award-info":[{"award-number":["82260378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Traumatic brain injury (TBI) is a neurological disorder that severely affects health and function. Acid\u2010sensing ion channels 1a (ASIC1a), a proton\u2010gated cation channel permeable to Na\n                      <jats:sup>+<\/jats:sup>\n                      and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      , has been implicated in chronic neurodegeneration after TBI. However, its specific role in post\u2010TBI neuroinflammation remains poorly defined. In this study, we investigated the mechanistic involvement of ASIC1a in neuronal pyroptosis following TBI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult male C57BL\/6 mice were subjected to controlled cortical impact (CCI) modeling using weight\u2010drop models. Expression of ASIC1a was evaluated by Western blot and immunofluorescence. Brain water content and neurobehavioral function were tested to assess brain edema and neurological performance. qRT\u2010PCR and Western blot were performed to evaluate the expression of pyroptosis and NF\u2010\u03baB\/NLRP3 pathway related markers. ELISA kits were used to measure the levels of IL\u20101\u03b2 and IL\u201018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrated that ASIC1a expression was upregulated following TBI and localized primarily in neurons. Furthermore, pharmacological inhibition of ASIC1a with PcTx1 significantly attenuated brain edema and improved neurological outcomes in TBI mice. Notably, inhibition of ASIC1a decreased the levels of the pyroptosis\u2010related protein GSDMD\u2010N, as well as the inflammatory cytokines IL\u20101\u03b2 and IL\u201018. Importantly, ASIC1a blockade was associated with the downregulation of the NF\u2010\u03baB\/NLRP3 signaling pathway, suggesting that ASIC1a inhibition alleviates neuroinflammatory injury potentially through the modulation of this axis both in\u00a0vivo and in\u00a0vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings implicate ASIC1a as an important modulator of neuroinflammatory progression following TBI. Furthermore, pharmacological inhibition of ASIC1a mitigates neuronal pyroptosis, an effect that is closely associated with the downregulation of the NF\u2010\u03baB\/NLRP3 axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70918","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:16:13Z","timestamp":1778847373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of\n                    <scp>ASIC1a<\/scp>\n                    Attenuates Neuronal Pyroptosis and Neuroinflammation Following Traumatic Brain Injury"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3055-7685","authenticated-orcid":false,"given":"Jiawei","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"Department of Critical Care Medicine Nanjing Drum Tower Hospital  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"},{"name":"Department of Neurosurgery, Jiangxi Provincial People's Hospital The First Affiliated Hospital of Nanchang Medical College  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi 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