{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T14:14:08Z","timestamp":1779804848383,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870905"],"award-info":[{"award-number":["81870905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effect of the difference between cystatin C\u2010 and creatinine\u2010based estimated glomerular filtration rates (eGFRdiff) on stroke outcomes is unclear. This study investigated the association between eGFRdiff and stroke prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants with ischaemic stroke or transient ischaemic attack were recruited from the Third China National Stroke Registry, a multicenter, prospective cohort. eGFRdiff was calculated using the absolute difference (eGFRabdiff defined as cystatin C\u2010based (eGFRcys) minus creatinine\u2010based (eGFRcr)) and the ratio (eGFRrediff) between eGFRcys and eGFRcr estimates. eGFRabdiff (&lt;\u2009\u221215, \u221215\u201315, \u2265\u200915\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ) and eGFRrediff (&lt;\u20090.6, \u2265\u20090.6) were analyzed. Time\u2010updated eGFRdiff (\u0394eGFRdiff) was defined as the change from baseline to 1\u2010year blood re\u2010examination and tertiled. Outcomes included 5\u2010year all\u2010cause mortality, stroke disability, and stroke recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 10,293 participants, 35.2% had an eGFRabdiff &lt;\u2009\u221215\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      , and 3.5% had an eGFRrediff &lt;\u20090.6. Compared with midrange eGFRabdiff, participants with eGFRabdiff &lt;\u2009\u221215\u2009mL\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      had an odds ratio (OR) of 1.19 (95% confidence interval (CI), 1.05\u20131.35) for disability and a hazard ratio (HR) of 1.28 (95% CI, 1.12\u20131.46) for mortality. eGFRrediff &lt;\u20090.6 was associated with a higher risk for disability (OR, 1.66; 95% CI, 1.25\u20132.19) and mortality (HR, 1.49; 95% CI, 1.17\u20131.90). Participants with the largest \u0394eGFRdiff declines had higher mortality (OR, 1.44; 95% CI, 1.14\u20131.82) and borderline disability risk significance (HR, 1.25; 95% CI, 0.96\u20131.61).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Significant and widening eGFRdiff were independently associated with increased risks of post\u2010stroke disability and mortality, highlighting the importance of monitoring eGFRcys and eGFRcr in stroke management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70930","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:51:09Z","timestamp":1779112269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Differences in Estimated\n                    <scp>GFR<\/scp>\n                    by Creatinine Vs. Cystatin C and Stroke Outcomes: Results From the Third China National Stroke Registry"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-2596","authenticated-orcid":false,"given":"Qi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-6789","authenticated-orcid":false,"given":"Yuesong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Capital Medical University  Beijing China"},{"name":"Department of Neurology, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National Clinical Research Center for Neurological Diseases  Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders  Beijing 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