{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:34Z","timestamp":1784127814176,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004479"],"award-info":[{"award-number":["82004479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012152","name":"National Postdoctoral Program for Innovative Talents","doi-asserted-by":"publisher","award":["BX20250215"],"award-info":[{"award-number":["BX20250215"]}],"id":[{"id":"10.13039\/501100012152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M783954"],"award-info":[{"award-number":["2025M783954"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to elucidate the potential mechanism, especially neural circuit mechanisms, through which electroacupuncture (EA) mitigates cognitive decline in a rat model of vascular cognitive impairment (VCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a rat two\u2010vessel occlusion (2VO) model, we assessed the therapeutic impact of EA on spatial and non\u2010spatial memory. We integrated in\u00a0vivo fiber photometry and immunofluorescence to monitor neuronal activities in the dentate gyrus (DG) and supramammillary nucleus (SuM), while Golgi staining was employed to evaluate hippocampal synaptic plasticity. Viral tracing and chemogenetic manipulations were utilized to characterize the functional necessity of the SuM\n                      <jats:sup>Glu<\/jats:sup>\n                      \u2010DG circuit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EA at ST36 significantly restored learning and memory function. This functional recovery was accompanied by improved synaptic plasticity and heightened neuronal activity in the DG. Fiber photometry revealed that EA specifically activated glutamatergic neurons in the SuM, a key upstream regulator of the DG. Notably, targeted chemogenetic inhibition of the SuM\n                      <jats:sup>Glu<\/jats:sup>\n                      \u2010DG circuit abolished the cognitive improvements typically induced by EA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings demonstrate that EA ameliorates learning and memory deficits in VCI through regulating the SuM\n                      <jats:sup>Glu<\/jats:sup>\n                      \u2010DG circuit.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70962","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:41:19Z","timestamp":1781325679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus\u2013Dentate Gyrus Circuit"],"prefix":"10.1002","volume":"32","author":[{"given":"Fang","family":"Wan","sequence":"first","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7819-2618","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7031-3446","authenticated-orcid":false,"given":"Jing\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-5667","authenticated-orcid":false,"given":"Cun\u2010Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"International Acupuncture and Moxibustion Innovation Institute, School of Acupuncture\u2010Moxibustion and Tuina Beijing University of Chinese Medicine  Beijing 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