{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:34Z","timestamp":1784127814292,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371295"],"award-info":[{"award-number":["82371295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500502"],"award-info":[{"award-number":["2021YFC2500502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate the characteristics, predictors, and clinical significance of periventricular anastomosis (PA) regression following revascularization in moyamoya disease (MMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a longitudinal cohort study involving patients with MMD treated at our hospital between 2019 and 2023. Demographic, radiological findings, and clinical outcomes were recorded. C\u2010terminal region of ring finger protein 213 (\n                      <jats:italic>RNF213<\/jats:italic>\n                      ) was sequenced. Additionally, structural changes of the\n                      <jats:italic>RNF213<\/jats:italic>\n                      variants were evaluated using a three\u2010dimensional model of the human RNF213 protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 305 eligible patients, 103 experienced postoperative PA regression. Among the subtypes of PA, those derived from the lenticulostriate, anterior choroidal, and thalamotuberal arteries exhibited significant regression. Multivariate analysis identified age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030), Suzuki stage (III\u2010IV) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), preoperative PA score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001),\n                      <jats:italic>RNF213<\/jats:italic>\n                      p.R4810K variant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), other\n                      <jats:italic>RNF213<\/jats:italic>\n                      rare variants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), and postoperative Matsushima grading (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were associated with postoperative PA regression. The risk of future hemorrhage was significantly higher in the non\u2010PA regression group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040). 80% of rare variants without structural changes did not exhibit PA regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>RNF213<\/jats:italic>\n                      variants in the C\u2010terminal region are associated with PA regression, underscoring a broader genotype\u2013phenotype correlation. Furthermore, PA regression might be considered a potential radiological marker to predict the risk of future hemorrhage in MMD patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70982","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:44:28Z","timestamp":1781325868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>RNF213<\/i>\n                    <\/scp>\n                    Variants Associated With Periventricular Anastomosis Regression After Revascularization in Moyamoya Disease"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1064-9012","authenticated-orcid":false,"given":"Youyuan","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"China National 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