{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:31:16Z","timestamp":1789507876495,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371361"],"award-info":[{"award-number":["82371361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371333"],"award-info":[{"award-number":["82371333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ\u2010 LZX0044"],"award-info":[{"award-number":["CSTB2025NSCQ\u2010 LZX0044"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016834","name":"Chongqing Municipal Health Commission","doi-asserted-by":"publisher","award":["YXGD202451"],"award-info":[{"award-number":["YXGD202451"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["cstc2024ycjh\u2010 bgzxm0103"],"award-info":[{"award-number":["cstc2024ycjh\u2010 bgzxm0103"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Cholesterol plays a critical role in repairing white matter injury (WMI) following traumatic brain injury (TBI). The enzyme cholesterol 24\u2010hydroxylase (CYP46A1) regulates the removal of cholesterol by converting it into 24(S)\u2010hydroxycholesterol (24OHC). Although CYP46A1 has neuroprotective effects on various central nervous system disorders, its effect on WMI remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult male C57BL\/6 mice underwent controlled cortical impact to model TBI. Experiments using the CYP46A1 activator efavirenz and CYP46A1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice were utilized to elucidate the function of CYP46A1. Neurological function, WMI, and cholesterol metabolism were evaluated, and the mechanisms through which CYP46A1 affects these processes were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Efavirenz markedly improved outcomes and preserved white matter structure after TBI by increasing microglial phagocytic activity and myelin debris clearance, along with promoting oligodendrocyte precursor cell remyelination. Furthermore, efavirenz promoted cholesterol export by increasing 24OHC levels and activating liver X receptors (LXR). However, these neuroprotective effects of Efavirenz were partially diminished when CYP46A1 was knocked down or when LXR activity was blocked.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efavirenz administration promotes functional neurological recovery and sustains white matter integrity in TBI through the regulation of cholesterol homeostasis and the promotion of remyelination processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70984","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:49:59Z","timestamp":1781588999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>CYP46A1<\/scp>\n                    \u2010Targeted Treatment Alleviates Long\u2010Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6488-1790","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Chonggang General Hospital, Chongqing University of Posts and Telecommunications  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Key Laboratory of Intelligent Diagnosis, Treatment and Rehabilitation of Central Nervous System Injuries, Southwest Hospital, Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Clinical 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