{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:17:34Z","timestamp":1784125054131,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474009"],"award-info":[{"award-number":["82474009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Global antidepressant use has risen substantially, raising concerns about their potential ocular adverse effects. Nevertheless, large\u2010scale comprehensive assessments of ocular side effects associated with various classes of antidepressants remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective pharmacovigilance analysis was performed using the FDA Adverse Event Reporting System (FAERS) from Q1 2015 to Q4 2024. Reports associated with antidepressants were systematically extracted, and disproportionality analyses were performed to identify potential associations with ocular adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>62,020 ocular AE reports were identified for 13,348 patients (median age, 44\u2009years), with higher susceptibility observed in females. Norepinephrine\u2013dopamine disinhibitors (NDDIs) showed the strongest association with eye disorders (IC 3.84, 95% CI 3.75\u20133.90), while selective serotonin reuptake inhibitors (SSRIs) showed the greatest number of positive associations across key ocular AEs. Analysis of the 36 antidepressants with sufficient case reports for ocular neuromuscular disorders revealed that 33 were associated with such disorders, most notably mydriasis, miosis, and anisocoria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study delineates the ocular risks of antidepressants, highlighting higher toxicity for NDDIs and SSRIs and widespread associations with ocular neuromuscular disorders. Vigilant monitoring and early intervention are warranted to ensure safe clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.70994","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:35:45Z","timestamp":1781699745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ocular Adverse Events Associated With Antidepressants: A Large\u2010Scale Data Analysis From the FAERS Database"],"prefix":"10.1002","volume":"32","author":[{"given":"Yiming","family":"Peng","sequence":"first","affiliation":[{"name":"Center of Clinical Pharmacology, Third Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Cao","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology, Third Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1985-6776","authenticated-orcid":false,"given":"Hanhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Third Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-1201","authenticated-orcid":false,"given":"Junlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Clinical Research Center for Geriatric Diseases, Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-586X","authenticated-orcid":false,"given":"Guoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Clinical Pharmacology, Third Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"World Mental Health Report: Transforming Mental Health for All","author":"World Health Organization","year":"2022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001738\u2010y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.104"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1576"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190287"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14475"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.104257"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291721003160"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014682.pub2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2010.1024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S431159"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010023\u201010177\u20104"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.061960"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(94)00170\u2010J"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301\u20104738.162612"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.3723"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2022.10482"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/eb\u20102016\u2010102528"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001325"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/11533180\u2010000000000\u201000000"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.615"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34837"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.20517\/jca.2023.33"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/amp0000904"},{"key":"e_1_2_12_26_1","volume-title":"Depression in Adults: Treatment and Management","author":"National Institute for Health and Care Excellence","year":"2022"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6682928"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08655"},{"key":"e_1_2_12_29_1","first-page":"1","article-title":"Antidepressant Use Among Persons Aged 12 and Over: United States, 2011\u20132014","volume":"283","author":"Pratt L. 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