{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:23Z","timestamp":1784127803285,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52500256"],"award-info":[{"award-number":["52500256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62522119"],"award-info":[{"award-number":["62522119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The long\u2010term association of central obesity with brain structural integrity remains poorly understood. This study aimed to investigate the longitudinal association between cumulative Weight\u2010adjusted\u2010waist Index (WWI) exposure and multi\u2010modal neuroimaging markers of brain health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective community\u2010based cohort study included 935 participants from the META\u2010KLS Study. Cumulative WWI was calculated as the time\u2010weighted average over 12\u2009years prior to MRI acquisition. Neuroimaging outcomes included regional gray matter volume, white matter hyperintensity (WMH), and diffusion tensor imaging (DTI) metrics. Generalized linear models, restricted cubic splines, and mediation analyzes were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Elevated cumulative WWI was associated with adverse brain structural outcomes, particularly in females. In women, higher WWI was linked to extensive WMH burden (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009=\u20090.002), widespread microstructural disintegration (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>FDR<\/jats:sub>\n                      \u2009=\u20090.023), and specific atrophy in the orbital frontal cortex. A J\u2010shaped dose\u2013response relationship was identified for white matter injury, suggesting a tipping point for metabolic resilience. In exploratory mediation analyzes, FBG, SBP, and hs\u2010CRP statistically accounted for 14.7%, 11.3%, and 11.3% of the association between cumulative WWI and WMH burden, respectively, while SBP accounted for 17.8% of the association with global MD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cumulative WWI serves as a potential predictor of adverse brain structural outcomes, particularly manifesting as white matter injury and atrophy in women. Early monitoring of WWI offers a vital window for targeted metabolic interventions to preserve brain structural integrity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71001","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:36:33Z","timestamp":1782228993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Weight\u2010Adjusted\u2010Waist Index With Brain Health: A 16\u2010Year Population\u2010Based Longitudinal Cohort Study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4171-4272","authenticated-orcid":false,"given":"Qi","family":"Sun","sequence":"first","affiliation":[{"name":"Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital Capital Medical University  Beijing China"},{"name":"Department of Radiology, Beijing Friendship Hospital Capital Medical University  Beijing 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