{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:00:08Z","timestamp":1785301208841,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify hippocampal intracranial electroencephalography (iEEG) signatures associated with mechanical ventilation (MV) in humans and rats and assess their translational relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hippocampal iEEG was recorded in humans (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) and rats (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912; MV\u2009+\u2009propofol vs. propofol\u2010only,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 per group). Power spectral density (PSD), spectral exponent (SE), and trajectory entropy (TE) were quantified to characterize MV\u2010related neural changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MV was associated with consistent directional hippocampal iEEG changes across species, with increased PSD, SE, and reduced TE. In humans, PSD increases were mainly posterior (delta\u2010alpha;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while in rats they spanned dorsal theta\u2010gamma (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). SE increased in humans (38.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rats (26.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), while TE decreased in humans (11.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rats (6.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Cross\u2010species differences were greater in the posterior\/dorsal hippocampus (PSD: d\u2009=\u2009\u22120.924 [\u22121.521 to \u22120.328]; SE: d\u2009=\u20090.944 [0.346 to 1.542]) than in anterior\/ventral regions. In rats, MV increased low\u2010frequency power and SE and reduced dorsal TE under propofol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MV is associated with comparable hippocampal iEEG changes across species, supporting the rat model for MV\u2010related neural dynamics. Nevertheless, the findings are EEG\u2010restricted and lack general translational validity for brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trail Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ClinicalTrails.gov\">ClinicalTrails.gov<\/jats:ext-link>\n                      (NCT06480162; Zhonghua Shi; May 8, 2024)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71012","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:01:07Z","timestamp":1784116867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical Ventilation\u2010Associated Changes in Hippocampal Electroencephalogram: A Cross\u2010Species Study in Humans and Rats"],"prefix":"10.1002","volume":"32","author":[{"given":"Xiang","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Department of Anesthesiology, Sanbo Brain Hospital Capital Medical University  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Ou","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traffic Data Mining and Embodied Intelligence, School of Computer Science and Technology Beijing Jiaotong University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing China"},{"name":"Department of Neurosurgery, Department of Intensive Care Medicine, Sanbo Brain Hospital Capital Medical University  Beijing 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Clinical Medicine Capital Medical University  Beijing China"},{"name":"Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traffic Data Mining and Embodied Intelligence, School of Computer Science and Technology Beijing Jiaotong University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Department of Anesthesiology, Sanbo Brain Hospital Capital Medical University  Beijing China"},{"name":"Laboratory for Clinical Medicine Capital Medical University  Beijing 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