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Motor function and limb coordination were assessed behaviorally. Transcriptomic and proteomic analyses of the peri\u2010infarct region were performed to explore mechanisms. Immunofluorescence and Western blot analyzed key proteins in the calcineurin\/AKT\/FOXO1 pathway, while TUNEL staining assessed neuronal apoptosis. AAV\u2010mediated gene knockdown was used to validate the pathway's role in apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>cTBS improved motor performance, reduced infarct volume, and preserved peri\u2010infarct tissue architecture. It suppressed calcineurin expression, enhanced calcineurin\/AKT\/FOXO1 pathway activation, and decreased neuronal apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>cTBS exerts neuroprotection by modulating the calcineurin\/AKT\/FOXO1 pathway, ultimately inhibiting neuronal apoptosis in the peri\u2010infarct region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71017","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:32:10Z","timestamp":1783513930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Protective Mechanism of Continuous Theta Burst Stimulation in the Acute Phase of Stroke Through Modulation of the Calcineurin\/\n                    <scp>AKT<\/scp>\n                    \/\n                    <scp>FOXO1<\/scp>\n                 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