{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:42:58Z","timestamp":1793281378697,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Thrombosis, characterized by pathological intravascular clot formation, underlies major clinical events such as cerebral infarction, myocardial infarction, and pulmonary embolism. However, metabolomic alterations associated with cerebral infarction, particularly those distinguishing patients with different clinical outcomes after recanalization, remain poorly characterized. This study aimed to provide an unbiased, systems\u2010level characterization of metabolic alterations in cerebral infarction thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed LC\u2013MS\/MS\u2010based untargeted plasma metabolomics in both positive and negative ion modes. The cohort included 24 patients with meaningful functional recovery after cerebral infarction thrombectomy (MFR), 21 patients with futile recanalization (FTR), and 20 healthy controls (CON). Global metabolomic profiles were analyzed using multivariate and univariate approaches, followed by KEGG pathway enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma metabolite profiles differed significantly among groups. Both MFR and FTR patients exhibited marked metabolic perturbations relative to controls, while the MFR group showed subtle but distinct metabolic patterns compared with FTR patients. Differential metabolites were enriched in pathways related to mitochondrial function, lipid signaling, amino acid metabolism, and inflammatory regulation, which are associated with endothelial function and thrombo\u2010inflammatory responses in cerebral infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies metabolic alterations associated with cerebral infarction thrombosis and clinical outcome status following recanalization. These findings highlight candidate metabolites and pathways that may inform future mechanistic studies and biomarker validation specific to cerebral infarction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71018","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:41:07Z","timestamp":1783604467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Metabolomics of Thrombectomy\u2010Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery"],"prefix":"10.1002","volume":"32","author":[{"given":"Min","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Nephropathy and Rheumatism The Affiliated Yongchuan Hospital of Chongqing Medical University General Practice School of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research General Practice School of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research General Practice School of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research General Practice School of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingzhi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research General Practice School of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Key Laboratory of Cerebrovascular Disease Research General Practice School of Chongqing Medical University  Chongqing 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