{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:07Z","timestamp":1793345527119,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M773445"],"award-info":[{"award-number":["2025M773445"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Insomnia involves impaired emotional attention, yet the underlying neurophysiological mechanisms remain unclear. This study investigated neurobehavioral characteristics of emotional processing in insomnia, specifically examining modulations by emotional valence and intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010five individuals with non\u2010clinical insomnia disorder\u00a0(NCID) and 22 normal controls (NC) performed a two\u2010choice oddball task with emotional images (varying in valence and intensity) during task\u2010state EEG recording. Phase\u2010amplitude coupling (PAC) and time\u2010frequency analyses were utilized to assess neural dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The NCID group responded averagely slower and showed distinct negative bias, with response being faster to negative versus positive affective images. PAC analysis confirmed a dual dysregulation: the NCID group showed significantly reduced delta\u2010beta coupling in frontal regions and significantly increased theta\u2010beta coupling in occipital regions. Importantly, these coupling alterations were intensity\u2010dependent; the NCID group showed a blunted dynamic range across intensities and lower frontal coupling specifically for high\u2010intensity negative stimuli. Time\u2010frequency analysis further revealed increased posterior theta power in the NCID group, while beta oscillations showed enhanced responses to negative stimuli in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Insomnia is characterized by altered emotional susceptibility involving intensity\u2010dependent alterations in cross\u2010frequency coupling (CFC). These findings clarify the neurophysiological mechanisms of emotional dysfunction in insomnia and highlight CFC as a potential biomarker for emotional regulation impairments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71031","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:25:27Z","timestamp":1785335127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreased Control and Enhanced Reactivity: Dual Dysregulation Pattern of Cross\u2010Frequency Coupling in Emotional Susceptibility of Non\u2010Clinical Insomnia"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-3013","authenticated-orcid":false,"given":"Siyu","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"},{"name":"Provincial Key Laboratory of Multimodal Perceiving and Intelligent Systems, College of Information Science and Engineering Jiaxing University  Jiaxing China"},{"name":"Lab of Light and Physio\u2010Psychological Health, National Center for International Research on Green Optoelectronics South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-0210","authenticated-orcid":false,"given":"Qingwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou China"},{"name":"Lab of Light and Physio\u2010Psychological Health, National Center for International Research on Green Optoelectronics South China 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