{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:49Z","timestamp":1793345569117,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Glymphatic dysfunction is increasingly recognized as a key contributor to the progression of Parkinson's disease (PD). In PD, both choroid plexus (CP) alterations and white matter abnormalities have been linked to glymphatic dysfunction. However, how CP microstructural abnormalities relate to glymphatic function, corpus callosum (CC) degeneration, and clinical impairment remains unclear. This study aimed to investigate these associations in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one patients with idiopathic PD and eighty age\u2010 and sex\u2010matched healthy controls (HC) underwent MRI scanning. CP microstructural metrics (free water [FW], FW\u2010corrected fractional anisotropy [FA\n                      <jats:sub>FWcorr<\/jats:sub>\n                      ] and FW\u2010corrected mean diffusivity [MD\n                      <jats:sub>FWcorr<\/jats:sub>\n                      ]) were extracted, along with the diffusion tensor image analysis along the perivascular space (DTI\u2010ALPS) index and CC subregional volumes. Group comparisons, partial correlation, multiple linear regression, and mediation analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with PD showed significantly higher CP FW and MD\n                      <jats:sub>FWcorr<\/jats:sub>\n                      values and a lower DTI\u2010ALPS index than HC. Higher CP MD\n                      <jats:sub>FWcorr<\/jats:sub>\n                      was associated with worse motor symptoms and poorer cognitive performance after covariate adjustment. Mediation analysis suggested that the ALPS index mediated the associations between CP microstructural alterations and CC subregional volumes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CP microstructural abnormalities were associated with DTI\u2010ALPS alterations, CC degeneration, and clinical impairment in PD. FW\u2010DTI metrics of the CP may provide useful imaging markers for characterizing CP\u2010related changes in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71039","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:40:50Z","timestamp":1788759650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6129-6191","authenticated-orcid":false,"given":"Suyi","family":"Zhou","sequence":"first","affiliation":[{"name":"7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-1916","authenticated-orcid":false,"given":"Zhiming","family":"Zhen","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences, Chinese Academy of Sciences  Beijing China"},{"name":"National Multimode Trans\u2010Scale Biomedical Imaging Center, Institute of Biophysics Chinese Academy of Sciences  Beijing China"},{"name":"Interdisciplinary Research Platform for Brain Cognitive Mechanisms and Brain\u2010Machine Integration, Institute of Biophysics Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-9369","authenticated-orcid":false,"given":"Peiyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-8675","authenticated-orcid":false,"given":"Zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Yang","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6513-2906","authenticated-orcid":false,"given":"Fengwei","family":"Yu","sequence":"additional","affiliation":[{"name":"7T Magnetic Resonance Imaging Translational Medical Center, Department of Radiology, Southwest Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Team, Siemens Healthineers Ltd.  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