{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:00:05Z","timestamp":1785301205180,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1104900"],"award-info":[{"award-number":["2022YFA1104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371175"],"award-info":[{"award-number":["82371175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20804"],"award-info":[{"award-number":["U24A20804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515030012"],"award-info":[{"award-number":["2023A1515030012"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515130007"],"award-info":[{"award-number":["2022B1515130007"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515040015"],"award-info":[{"award-number":["2023B1515040015"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD), the most common form of dementia, remains without effective therapies. Dysregulated eukaryotic elongation factor 2 kinase\/eukaryotic elongation factor 2 (eEF2K\/eEF2) pathway leads to aberrant protein synthesis and impaired neuronal function in AD, positioning this axis as a promising therapeutic target. However, effective pharmacological modulators of eEF2K\/eEF2 remain limited. Betulinaldehyde (Betu), an active ingredient derived from traditional Chinese medicine, remains to be thoroughly evaluated as a potential neuroprotective agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to investigate the therapeutic effects of Betu on AD and determine whether its activities are mediated through the eEF2K\/eEF2 pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Neuronal cell models were used to assess the effects of Betu on \u03b2\u2010amyloid 42 (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      )\u2010induced neuronal death, dendritic spine damage, protein synthesis inhibition, and eEF2 hyperphosphorylation. The eEF2K agonist nelfinavir (NFV) and the protein synthesis inhibitors cycloheximide (CHX) and anisomycin (AS) were used to investigate the involvement of the eEF2K\/eEF2 pathway and its regulated protein synthesis in the action of Betu. The cellular thermal shift assay (CETSA) was used to detect potential interactions between Betu and eEF2K. Additionally, the effects of Betu on reactive oxygen species (ROS) levels and the associated pathways were evaluated. An A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced mouse model of AD was used to evaluate the in\u00a0vivo effects of Betu on cognitive decline, hippocampal neuropathological damage, and eEF2 hyperphosphorylation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Betu significantly ameliorated the A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced neuronal death and dendritic spine damage, restored protein synthesis, and reversed eEF2 hyperphosphorylation. The neuroprotective effects of Betu were effectively inhibited by the CHX, AS, or NFV treatment, and CETSA supported a potential interaction between Betu and eEF2K. Furthermore, Betu reversed A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced ROS accumulation and upregulated nuclear factor\u2010like 2 and heme oxygenase\u20101, potential downstream effectors of the eEF2K pathway. In an A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced AD mouse model, Betu treatment markedly ameliorated cognitive decline, concomitant with attenuated neuropathological damage and restored eEF2 phosphorylation in the hippocampus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate that Betu protects against A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \u2010induced neurotoxicity by modulating the eEF2K\/eEF2 pathway, highlighting its potential as a lead compound for AD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71050","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:08:11Z","timestamp":1785164891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Betulinaldehyde Ameliorates A\u03b2\u2010Induced Neurotoxicity and Cognitive Deficits by Modulating the\n                    <scp>eEF2K<\/scp>\n                    \/\n                    <scp>eEF2<\/scp>\n                    Pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Chaoqun","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biology Hong Kong Baptist University  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-0863","authenticated-orcid":false,"given":"Yaping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-4680","authenticated-orcid":false,"given":"Zhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Teaching and Research Division, School of Chinese Medicine Hong Kong Baptist University  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Law Sau Fai Institute for Advancing Translational Medicine in Bone &amp; Joint Diseases (TMBJ) Hong Kong Baptist University  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-6500","authenticated-orcid":false,"given":"Zhi\u2010Ri","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Intelligent Systems Science and Engineering Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Kin\u2010Lam","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Science and Environmental Studies The Education University of Hong Kong  Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0785-5461","authenticated-orcid":false,"given":"Shiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-3432","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs Jinan University  Guangzhou China"},{"name":"JNU\u2010HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Pharmacodymamic Constituents of TCM &amp; New Drugs Research, Guangdong Hong Kong\u2010Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.743573"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2024.100176"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01858-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102051"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.106553"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abc5429"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01208-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-78652-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04784-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1694-14.2014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04833.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.036"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122954"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15541"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.061"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1634-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02299-8"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16300"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27580-w"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116148"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14101426"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305632"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202154543"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00044"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.4c00635"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0472-7"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(86)90027-6"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-026-03517-3"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032912"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.304"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.08.011"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.11.016"},{"issue":"5","key":"e_1_2_12_35_1","article-title":"Discovery of Novel eEF2K Inhibitors Using HTS Fingerprint Generated From Predicted Profiling of Compound\u2010Protein Interactions","volume":"8","author":"Yoshimori A.","year":"2021","journal-title":"Medicine"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104813"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27160-4"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.09.031"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718531115"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14034"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2024.168886"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05153-5"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70329"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1366061"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01285-7"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128759"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-020-01917-8"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01484-7"},{"issue":"5","key":"e_1_2_12_49_1","article-title":"Design and Characterization of a Novel eEF2K Degrader With Potent Therapeutic Efficacy Against Triple\u2010Negative Breast Cancer","volume":"11","author":"Zhong C.","year":"2024","journal-title":"Advancement of Science"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70033"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215091"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0554-9"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13916"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174637"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.07.027"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.123"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.71050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:14:39Z","timestamp":1785298479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.71050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cns.71050"],"URL":"https:\/\/doi.org\/10.1002\/cns.71050","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71050"}}