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FTO\u2010mediated m\n                      <jats:sup>6<\/jats:sup>\n                      A modification is involved in the pathological processes of NP. These findings suggest that FTO may serve as a potential therapeutic target for neurological disorders and NP. Common mechanisms may include the regulation of downstream mTOR and BDNF\/TrkB signaling pathways, as well as modulation of neuronal excitability and synaptic plasticity. However, research on the relationship between exercise and m\n                      <jats:sup>6<\/jats:sup>\n                      A modification remains in its early stages. Emerging evidence suggests that exercise reduces FTO expression and increases m\n                      <jats:sup>6<\/jats:sup>\n                      A levels in the hippocampus and hypothalamus, indicating that exercise may serve as an effective intervention for modulating epigenetic modifications in the central nervous system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This implies that exercise may serve as an effective intervention for modulating epigenetic modifications, potentially by downregulating the demethylase FTO, regulating m\n                      <jats:sup>6<\/jats:sup>\n                      A modification, enhancing synaptic plasticity, modulating neuronal excitability, and providing neuroprotection, thereby contributing to disease mitigation. We hypothesize that exercise may regulate neurological disorders and NP through FTO\u2010mediated m\n                      <jats:sup>6<\/jats:sup>\n                      A modification, with FTO potentially serving as a biomarker.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71051","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:40:32Z","timestamp":1785152432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exercise, Demethylase\n                    <scp>FTO<\/scp>\n                    , Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-9844","authenticated-orcid":false,"given":"Yanan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine The First Affiliated Hospital of 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