{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:19:20Z","timestamp":1787901560271,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102690"],"award-info":[{"award-number":["82102690"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515011575"],"award-info":[{"award-number":["2026A1515011575"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21626406"],"award-info":[{"award-number":["21626406"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the therapeutic effects of NAP2, a novel NgR1 antagonist peptide, on Alzheimer's disease (AD) pathology and to determine whether inhibition of the Nogo\u2010A\/NgR1\/ROCK signaling axis can ameliorate neurodegenerative alterations in APP\/PS1 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>APP\/PS1 transgenic mice received a three\u2010month NAP2 intervention. Cognitive performance was assessed using standard learning and memory tests. Amyloid\u2010\u03b2 plaque burden, dendritic spine density, tau phosphorylation, and A\u03b242 levels were examined by histological and biochemical analyses. Mitochondrial function and downstream ROCK signaling activity were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NAP2 treatment significantly improved cognitive performance in APP\/PS1 mice. NAP2 reduced amyloid\u2010\u03b2 plaque deposition, decreased A\u03b242 expression, and increased hippocampal dendritic spine density. Tau hyperphosphorylation was notably attenuated. In addition, NAP2 alleviated A\u03b242\u2010induced mitochondrial dysfunction. Mechanistic studies revealed that NAP2 interfered with ROCK signaling downstream of Nogo\u2010A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NAP2 ameliorates multiple AD\u2010related pathological features, an effect accompanied by the inhibition of the Nogo\u2010A\/NgR1\/ROCK pathway. These findings highlight the therapeutic potential of NAP2 to enhance resilience against Alzheimer's disease pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71052","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:31:08Z","timestamp":1786689068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Nogo\u2010A Receptor Antagonist Peptide Impedes Alzheimer's Disease Pathology by Nogo\u2010A\/\n                    <scp>NgR<\/scp>\n                    \/\n                    <scp>ROCK<\/scp>\n                    Signaling Pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Jinan University, Jinan University  Guangzhou Guangdong Province 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