{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:14Z","timestamp":1793345534227,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insomnia disorder (ID) is characterized by hyperarousal, yet the relationship between cortical excitability and large\u2010scale network dynamics remains incompletely understood. While fMRI studies indicate network alterations in ID, high\u2010temporal\u2010resolution characterization of these dynamics across the sleep\u2013wake cycle is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010six patients with ID and 29 healthy controls underwent eyes\u2010closed resting\u2010state OPM\u2010MEG recordings during evening (pre\u2010sleep) and morning (post\u2010awakening) sessions. We analyzed the aperiodic spectral exponent to index cortical excitability and employed microstate analysis to quantify fast network dynamics. A mediation analysis was conducted to explore the associations between electrophysiological features and sleep quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to controls, patients with ID exhibited a significantly flatter aperiodic power spectrum in the evening, suggesting elevated cortical excitability. Microstate analysis revealed distinct spatiotemporal alterations: (1) an evening\u2010specific increase in the coverage of a putative temporal\u2010limbic microstate, and (2) a sustained elevation of a putative sensorimotor microstate observed in both evening and morning sessions. Mediation analysis indicated that the altered evening limbic microstate dynamics statistically mediated the association between the aperiodic exponent and subjective sleep disturbance measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that ID involves concurrent disruptions in aperiodic neural activity and microstate temporal organization. The study highlights distinct diurnal profiles for putative sensorimotor and limbic network alterations, suggesting that OPM\u2010MEG can effectively capture the multifaceted electrophysiological signatures of the insomnia phenotype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71066","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:13:31Z","timestamp":1785402811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Evening Aperiodic Activity and Microstate Dynamics in Insomnia Disorder: An\n                    <scp>OPM MEG<\/scp>\n                    Study"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-5902","authenticated-orcid":false,"given":"Feng","family":"Cui","sequence":"first","affiliation":[{"name":"Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School Nanjing University  Suzhou China"},{"name":"Suzhou Hospital, Affiliated Hospital of Medical School Nanjing University  Suzhou China"},{"name":"School of Biomedical Engineering (Suzhou), Division of Life Science and Medicine University of Science and Technology of China  Hefei China"},{"name":"Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Emergency &amp; 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