{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:19:56Z","timestamp":1787901596025,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371255"],"award-info":[{"award-number":["82371255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      N6\u2010methyladenosine (m\n                      <jats:sup>6<\/jats:sup>\n                      A) facilitates functional recovery following ischemic stroke (IS). This study investigated the role of\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      in post\u2010stroke cognitive impairment (PSCI) and the mechanisms regarding m\n                      <jats:sup>6<\/jats:sup>\n                      A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      HT\u201022 cell damage and ferroptosis were analyzed following OGD exposure. pMCAO surgery was performed to establish an IS mouse model. We assessed neurological deficits and cognitive impairment in mice using the mNSS, adhesive removal test, rotarod test, novel object recognition test, and Y\u2010maze test. Adeno\u2010associated viral vectors with overexpression of\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      combined with pMCAO surgery were used to analyze cognitive dysfunction and ferroptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      was reduced in neurons of PSCI mice.\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      overexpression alleviated ferroptosis\u2010induced neuronal damage by promoting the membrane translocation of Slc7a11. Hnrnpa2b1 promoted\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      stability through an m\n                      <jats:sup>6<\/jats:sup>\n                      A\u2010related mechanism. Knockdown of\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      reversed the mitigation of ferroptosis by\n                      <jats:italic>Hnrnpa2b1<\/jats:italic>\n                      and exacerbated the neuronal injury. Under OGD,\n                      <jats:italic>Bard1<\/jats:italic>\n                      knockdown reduced the Hnrnpa2b1 ubiquitination, slowed Hnrnpa2b1 degradation, and restored Sptbn2 expression. Knockdown of\n                      <jats:italic>Bard1<\/jats:italic>\n                      alleviated neuronal ferroptosis, thereby reducing the development of cognitive impairment in mice, a phenotype reversed by\n                      <jats:italic>Hnrnpa2b1<\/jats:italic>\n                      or\n                      <jats:italic>Sptbn2<\/jats:italic>\n                      knockdown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In IS, Bard1\u2010associated regulation of Hnrnpa2b1 ubiquitination is accompanied by reduced Sptbn2 expression and impaired Slc7a11 membrane translocation, and is involved in neuronal ferroptosis\u2010related damage.<\/jats:p>\n                  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