{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:07Z","timestamp":1793345527110,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431549029\u2010SFB 1451"],"award-info":[{"award-number":["431549029\u2010SFB 1451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine how lesion size and location shape longitudinal functional connectivity (FC) changes after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult male mice underwent atlas\u2010based resting\u2010state fMRI at baseline and 1, 2, and 4\u2009weeks after either a small photothrombotic cortical stroke (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200925) or a larger transient cortico\u2010striatal MCAO stroke (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20096). FC was quantified across 98 atlas regions, focusing on sensorimotor cortex, striatum, and thalamus, including intra\u2010 and inter\u2010hemispheric connectivity matrices and regional seed strength.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cortical stroke caused widespread hyperconnectivity at Weeks 1\u20132, with about 90% of connections increased, followed by partial normalization by Week 4. This effect declined most strongly in the ischemic hemisphere and remained more sustained contralesionally. In contrast, cortico\u2010striatal stroke induced global hypoconnectivity at Week 1, with more than 90% of connections decreased, a modest and heterogeneous shift toward baseline at Week 2, and widespread decreases persisting at Week 4. A subset of sensorimotor connections showing opposite changes in the two models robustly separated groups at all post\u2010stroke time points. Regional lesion involvement scaled with the magnitude of baseline\u2010referenced FC alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lesion topography drives distinct longitudinal FC trajectories after stroke and may help define network biomarkers and optimal windows for targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71114","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:39:01Z","timestamp":1787891941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Functional Connectivity Changes in Cortical and Cortico\u2010Striatal Strokes in Mice"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9886-9692","authenticated-orcid":false,"given":"Fatemeh S. N.","family":"Mahani","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM\u20103), Research Centre Juelich  Juelich Germany"},{"name":"Department of Neurology, Faculty of Medicine University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"Department of Neurology, Experimental Neurology Section Goethe University Frankfurt and University Hospital  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Diedenhofen","sequence":"additional","affiliation":[{"name":"In\u2010Vivo\u2010NMR Laboratory Max Planck Institute for Metabolism Research  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Green","sequence":"additional","affiliation":[{"name":"In\u2010Vivo\u2010NMR Laboratory Max Planck Institute for Metabolism Research  Cologne 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