{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:32:52Z","timestamp":1793345572162,"version":"4.5.0"},"reference-count":250,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia among the elderly, characterized by a gradual decline in memory and cognitive function. The growing body of evidence highlighting the interaction between the gut microbiota and the central nervous system has positioned the gut microbiota as a key area of research in AD pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review critically evaluates the preclinical evidence and clinical trial outcomes, complemented by mechanistic studies and Mendelian randomization analyses, to assess the therapeutic potential of nutritional interventions targeting the gut\u2010microbiota\u2010brain axis in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dietary components and patterns regulate the composition and function of the gut microbiota, which in turn influence brain function through the gut\u2010microbiota\u2010brain axis via chemical\/metabolic, immune\u2010mediated, and neural pathways. Specific nutrients, microbial metabolites, and dietary patterns have been shown to exert either protective or detrimental effects on AD pathology and cognitive function. Emerging strategies, including precision nutrition, fecal microbiota transplantation, and next\u2010generation microbiome\u2010based therapies, offer new avenues for AD prevention and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nutritional interventions targeting the gut\u2010microbiota\u2010brain axis represent a promising approach for the comprehensive prevention and management of AD. Further mechanistic and clinical studies are warranted to translate these findings into effective therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71117","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T15:37:28Z","timestamp":1788104248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulating the Gut\u2010Microbiota\u2010Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-0011","authenticated-orcid":false,"given":"Binyue","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangling","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6155-2103","authenticated-orcid":false,"given":"Jiesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S200490"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v8.i3.240"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1424"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60461-5"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrleng.2019.11.006"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.07.002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161141"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.10.020"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142841"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0534-0"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000139"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.08.019"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41802"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06246"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30028"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00008-07"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1848158"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.22.011602.092259"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2003.08.004"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-019-0110-9"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8050317"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180176"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-022-00323-z"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu3100858"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203657"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1415565"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240082"},{"key":"e_1_2_14_34_1","article-title":"Pathogenic Microbes, the Microbiome, and Alzheimer's Disease (AD)","volume":"6","author":"Hill J. M.","year":"2014","journal-title":"Frontiers in Aging Neuroscience"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00009"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01544"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47683-w"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41283-w"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326269"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03458-22"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01769-9"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9478630"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2098249"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-018-8032-4"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8063647"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.05.008"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00632-19"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203826"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100398"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO00886C"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00178-25"},{"issue":"2","key":"e_1_2_14_52_1","first-page":"1131","article-title":"Soluble Epoxide Hydrolase Inhibition Improves Alzheimer's Disease Hallmarks: Correlation With Peripheral Inflammation and Gut Microbiota Modulation","volume":"17","author":"Jarne\u2010Ferrer J. L. A.","year":"2025","journal-title":"Aging and Disease"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70406"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.08.051"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S374024"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200265"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2021.1991556"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2022.2103608"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.31083\/JIN48598"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03426-8"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251372522"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2605768"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00725-5"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00977-x"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00040-6"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2025.101481"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2303853"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.02.031"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae165"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12306"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003391"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01064"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2026.102781"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70057"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1422350"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040980"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad112"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17219"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1273104"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/25424823241310719"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251360004"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215411"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1414977"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251401157"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251372945"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.113"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020244"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000048685"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2025.150009"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i16.2780"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/25424823261422629"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16223929"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1423707"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-240071"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S580890"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02999-0"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16193312"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1306048"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01961-8"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1433131"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.02.019"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.006"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2025.12921"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03454-y"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118861"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2025.102708"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01333-3"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1334887"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2025.102588"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00214.2021"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102843"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00044"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2026.116224"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00307-1"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-111217"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000001007"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17071108"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2024.09.015"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1039\/D6FO00928J"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1017\/gmb.2025.10005"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.03.015"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205016666190315093520"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24122316"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1019942"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12814"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02283"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12040860"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO06134A"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300104"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020240"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2026.109097"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2024.01.020"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-231381"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac107"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.2174\/011570159X416900251207210728"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1677197"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665126102249"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00097.2025"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1367086"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.753351"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2026.03.008"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000624"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177787"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.003"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd5046"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202300601"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0216-x"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2026.128481"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02289-5"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102810"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01880-x"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-026-00866-3"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c09878"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14010101"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115498"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04847"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202200767"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2022.06.003"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-026-02342-8"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom16010018"},{"key":"e_1_2_14_162_1","article-title":"Fecal Short\u2010Chain Fatty Acids Vary by Sex and Amyloid Status","author":"Kuehn J. F.","year":"2025","journal-title":"medRxiv"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110080"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1400909"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16148"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1134082"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111499"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2020.0057"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210324"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061297"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04757.x"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.58.287"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.17"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.1539"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00042-15"},{"key":"e_1_2_14_180_1","first-page":"301","article-title":"Trimethylamine N\u2010Oxide (TMAO) in Human Health","volume":"20","author":"Gatarek P.","year":"2021","journal-title":"EXCLI Journal"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2020.04.007"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba3683"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0451-2"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20000"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1465457"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12768"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12918-016-0307-y"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.086101"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.10.022"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01181-z"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2023.03.005"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010026\u201001266\u20105"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101397"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01309-7"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.116"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-05074-2"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003652"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01172-0"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170248"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182904f69"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz054"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980011002515"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17243929"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.18992.1"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361601"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.04.011"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2323752"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13007"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.07.004"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093166"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200337"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00311-y"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.006"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.019"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15234915"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-231457"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70706"},{"issue":"4","key":"e_1_2_14_218_1","article-title":"Precision Nutrition for Management of Cognitive Impairment","volume":"3","author":"Xu J.","year":"2024","journal-title":"Precision Nutrition"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17193068"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041362"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70216"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1653841"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdad2030028"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2025.08.007"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104365"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01036-9"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics8040077"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102888"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14091559"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0525-3"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317431"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6c00173"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9122548"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.70012"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70259"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1703708"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2025.101049"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1103189"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520925930"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2021.1957807"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1281233"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13081956"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2517377"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-025-00244-1"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.3389\/frmbi.2026.1863308"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hsr.2025.100251"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2431648"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11122854"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1822743"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02474-7"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gutmic.2026.100005"}],"container-title":["CNS Neuroscience &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cns.71117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cns.71117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:07:52Z","timestamp":1793344072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cns.71117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":250,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cns.71117"],"URL":"https:\/\/doi.org\/10.1002\/cns.71117","archive":["Portico"],"relation":{},"ISSN":["1755-5930","1755-5949"],"issn-type":[{"value":"1755-5930","type":"print"},{"value":"1755-5949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"2026-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71117"}}