{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:57:08Z","timestamp":1791305828886,"version":"4.3.1"},"reference-count":99,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS131169"],"award-info":[{"award-number":["NS131169"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS124673"],"award-info":[{"award-number":["NS124673"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX006534"],"award-info":[{"award-number":["BX006534"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RD003028"],"award-info":[{"award-number":["RD003028"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CNS Neurosci Ther"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As population aging accelerates worldwide, the prevalence and burden of neurodegenerative diseases (NDs) continue to rise, underscoring the urgent need to identify key molecular mechanisms driving disease progression and novel therapeutic targets. Chronic neuroinflammation is a hallmark of multiple NDs, including Alzheimer's disease and Parkinson's disease. Platelet factor 4 (PF4) is a chemokine primarily released by activated platelets and has traditionally been investigated for its roles in hemostasis, thrombosis, and peripheral inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Growing evidence has implicated PF4 in the pathogenesis of NDs. Altered PF4 expression has been observed across multiple NDs. As a central player at the intersection of the nervous, immune, and vascular systems, PF4 modulates inflammation, vascular homeostasis, and neuronal survival, all of which are critical in the pathogenesis of NDs. Dissecting the cell\u2010type specific and temporally dynamic roles of PF4 across diverse disease contexts is essential for elucidating its contribution to neurodegenerative processes and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights PF4 as a potential mechanistic mediator in NDs and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cns.71118","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:39:19Z","timestamp":1791304759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2772-4741","authenticated-orcid":false,"given":"Qi","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Neurology, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Geriatric Research, Education and Clinical Center Veterans Affairs Pittsburgh Health Care System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-329X","authenticated-orcid":false,"given":"Yanji","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Westchester Medical Center New York Medical College  Valhalla New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-6243","authenticated-orcid":false,"given":"Xiaoming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Geriatric Research, Education and Clinical Center Veterans Affairs Pittsburgh Health Care System  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","first-page":"2937","article-title":"The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need","volume":"16","author":"Wang S.","year":"2024","journal-title":"Aging and Disease"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105225","article-title":"Systematic Review and Meta\u2010Analysis of Human Transcriptomics Reveals Neuroinflammation, Deficient Energy Metabolism, and Proteostasis Failure Across Neurodegeneration","volume":"149","author":"Noori A.","year":"2021","journal-title":"Neurobiology of Disease"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.semcdb.2019.05.004","article-title":"Microglia\u2010Mediated Neuroinflammation in Neurodegenerative Diseases","volume":"94","author":"Subhramanyam C. 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